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Tbio
HAUS6
HAUS augmin-like complex subunit 6

Protein Summary
Description
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
transcription factor perturbation
0.74
drug perturbation
0.71
kinase perturbation
0.71
microRNA
0.7


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Target Illumination GWAS Analytics (TIGA)
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GENEVA
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.47   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.47   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
2
1
91.9
prostate carcinoma
1
1
0
1.1
50.3
mean platelet volume
1
1
1
40
pulse pressure measurement
1
1
1
36
platelet count
1
1
1
27.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
91.9
prostate carcinoma
0
1.1
50.3
mean platelet volume
1
40
pulse pressure measurement
1
36
platelet count
1
27.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 6
VGNC:4758
473117
Macaque
HAUS augmin like complex subunit 6
712557
Mouse
MGI:1923389
230376
Dog
HAUS augmin like complex subunit 6
VGNC:41606
100856608
Horse
HAUS augmin like complex subunit 6
VGNC:18701
100063596
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HAUS augmin like complex subunit 6
Macaque
HAUS augmin like complex subunit 6
Mouse
Dog
HAUS augmin like complex subunit 6
Horse
HAUS augmin like complex subunit 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z4H7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (13)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (166)
1 – 10 of 166
HAUS7
Tbio
Novelty: 1.11657571
p_int: 0.999985518
p_ni: 0.000014482
Score: 0.998
Data Source: BioPlex,STRINGDB
RNF10
Tbio
Novelty: 0.09086567
p_int: 0.995191633
p_ni: 0.004808367
Data Source: BioPlex
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.976352832
p_ni: 0.023647168
Score: 0.334
Data Source: BioPlex,STRINGDB
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.945096445
p_ni: 0.054903555
Data Source: BioPlex
NPAS1
Tbio
Family: TF
Novelty: 0.08014425
p_int: 0.911408515
p_ni: 0.088591485
Score: 0.188
Data Source: BioPlex,STRINGDB
PRELID2
Tdark
Novelty: 0.38276284
p_int: 0.843964156
p_ni: 0.156035844
Data Source: BioPlex
DISC1
Tbio
Novelty: 0.00183442
p_int: 0.783344685
p_ni: 0.216655315
Data Source: BioPlex
MLF1
Tbio
Novelty: 0.0239522
p_int: 0.771928776
p_ni: 0.228071224
Score: 0.512
Data Source: BioPlex,STRINGDB
HAUS1
Tbio
Novelty: 0.11356375
Score: 0.999
Data Source: STRINGDB
HAUS5
Tbio
Novelty: 0.99720546
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.47

PubMed score by year
PubTator Score  7.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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