Protein Summary
IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]
- ENST00000395737
- ENSP00000379086
- ENSG00000128165
- ENST00000395738
- ENSP00000379087
- AM2
- AM2
- dJ579N16.4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.76 | ||
tissue sample | 0.66 | ||
gene perturbation | 0.62 | ||
cell line | 0.54 | ||
PubMedID | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 438 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 157 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 438 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 157 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (138)
Nearest Tclin Targets
Pathways (7)
Reactome (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Calcitonin-like ligand receptors | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Calcitonin-like ligand receptors | ||||
Class B/2 (Secretin family receptors) | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (1)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 5 | 7 | 8 | 99 | |||||
mean reticulocyte volume | 1 | 4 | 4 | 97.6 | |||||
red blood cell distribution width | 4 | 4 | 4 | 95.6 | |||||
mean corpuscular hemoglobin | 3 | 3 | 3 | 94.6 | |||||
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 91.5 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 8 | 99 | |||||
mean reticulocyte volume | 4 | 97.6 | |||||
red blood cell distribution width | 4 | 95.6 | |||||
mean corpuscular hemoglobin | 3 | 94.6 | |||||
mean corpuscular hemoglobin concentration | 2 | 91.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2675256 | 223780 | ||||||
Rat | RGD:1302971 | 399475 | ||||||
Dog | adrenomedullin 2 | VGNC:37661 | 606919 | |||||
Horse | adrenomedullin 2 | VGNC:15123 | 100629546 | |||||
Cow | adrenomedullin 2 | VGNC:25682 | 618896 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | adrenomedullin 2 | |||||
Horse | adrenomedullin 2 | |||||
Cow | adrenomedullin 2 | |||||
Publication Statistics
PubMed Score 438.00
PubMed score by year
PubTator Score 173.57
PubTator score by year
Related Publications
Text Mined References (48)
GeneRif Annotations (34)
Items per page:
0 of 0
PMID | Year | Title |
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