Tbio ADM2 ADM2

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Adm2

DTO Classes

Protein / Signaling / Hormone / Adm2

Protein Summary

Description

IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• Q7Z4H4
• Q3LFQ0

Gene Name

• ADM2

Ensembl ID

• ENST00000395737
• ENSP00000379086
• ENSG00000128165
• ENST00000395738
• ENSP00000379087

Symbol

• AM2
• AM2
• dJ579N16.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
tissue sample	0.66
gene perturbation	0.62
cell line	0.54
PubMedID	0.53

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 431.92   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 431.92   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	adrenomedullin 2	MGI:2675256	223780
Rat	adrenomedullin 2	RGD:1302971	399475
Dog	adrenomedullin 2	VGNC:37661	606919
Horse	adrenomedullin 2	VGNC:15123	100629546
Cow	adrenomedullin 2	VGNC:25682	618896

Species	Name	OMA	EggNOG	Inparanoid
Mouse	adrenomedullin 2
Rat	adrenomedullin 2
Dog	adrenomedullin 2
Horse	adrenomedullin 2
Cow	adrenomedullin 2

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q7Z4H4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)

Reactome (7)

Calcitonin-like ligand receptors (R-HSA-419812)

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Items per page:

5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Calcitonin-like ligand receptors	11 targets	R-HSA-419812
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	G alpha (s) signalling events	577 targets	R-HSA-418555
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792

Name	Explore in Pharos	Explore in Source
Calcitonin-like ligand receptors	11 targets	R-HSA-419812
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
G alpha (s) signalling events	577 targets	R-HSA-418555
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792

Gene Ontology Terms (12)

Functions (2)

Components (1)

Processes (9)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	UniProtKB
hormone activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (138)

Explore Interacting Targets

1 – 10 of 138

• See Interactions on String-DB

ADM

Tbio

Novelty: 0.0004958

Score: 0.983

Data Source: STRINGDB

CALCRL

Tclin

Family: GPCR

Novelty: 0.00568602

Score: 0.981

Data Source: Reactome,STRINGDB

RAMP3

Tclin

Novelty: 0.01616194

Score: 0.977

Data Source: Reactome,STRINGDB

RAMP2

Tclin

Novelty: 0.01086538

Score: 0.976

Data Source: Reactome,STRINGDB

RAMP1

Tclin

Novelty: 0.00831253

Score: 0.973

Data Source: STRINGDB

CALCA

Tbio

Novelty: 0.00010496

Score: 0.972

Data Source: STRINGDB

CALCA

Tclin

Novelty: 0.00010496

Score: 0.972

Data Source: STRINGDB

IAPP

Tbio

Novelty: 0.0005195

Score: 0.967

Data Source: STRINGDB

CALCB

Tclin

Novelty: 0.02069808

Score: 0.953

Data Source: STRINGDB

CALCR

Tclin

Family: GPCR

Novelty: 0.00112487

Score: 0.953

Data Source: STRINGDB

Publication Statistics

PubMed Score  431.92

PubMed score by year

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PubTator Score  173.57

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Amidation
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Hormone
Reference proteome
Secreted
Signal

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
endocrine/exocrine gland phenotype
reproductive system phenotype