Tchem ADM2 ADM2

Protein Summary

Description

IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• Q7Z4H4
• Q3LFQ0

Gene Name

• ADM2

Ensembl ID

• ENST00000395737
• ENSP00000379086
• ENSG00000128165
• ENST00000395738
• ENSP00000379087

Symbol

• AM2
• AM2
• dJ579N16.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
tissue sample	0.66
gene perturbation	0.62
cell line	0.54
PubMedID	0.53

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Adm2

DTO Classes

Protein / Signaling / Hormone / Adm2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 934.34   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 934.34   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0