Tbio COMMD6 COMM domain-containing protein 6

Protein Summary

Description

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]

Uniprot Accession IDs

• Q7Z4G1
• A6NF28
• B7ZLN0
• Q5TBK4

Gene Name

• COMMD6

Ensembl ID

• ENST00000355801
• ENSP00000348054
• ENSG00000188243
• ENST00000377615
• ENSP00000366841
• ENST00000406936
• ENSP00000385660

Symbol

• Acrg

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.77
virus perturbation	0.76
small molecule perturbation	0.66
cell type or tissue	0.64
tissue sample	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.81   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 24   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.81   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0