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Tbio
LRP10
Low-density lipoprotein receptor-related protein 10

Protein Summary
Description
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359591
  • ENSP00000352601
  • ENSG00000197324
  • ENST00000546834
  • ENSP00000447559

Symbol
  • LRP9
  • LRP-10
  • MST087
  • MSTP087
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
transcription factor perturbation
0.84
histone modification site profile
0.82
gene perturbation
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.26   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.26   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
5.7
91
mathematical ability
4
4
5
88.6
heel bone mineral density
3
1
3
81.2
cup-to-disc ratio measurement
2
2
2
78.7
Dupuytren Contracture
1
1
0
1.3
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
5.7
91
mathematical ability
5
88.6
heel bone mineral density
3
81.2
cup-to-disc ratio measurement
2
78.7
Dupuytren Contracture
0
1.3
71.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LDL receptor related protein 10
VGNC:12552
452788
Macaque
LDL receptor related protein 10
712506
Mouse
MGI:1929480
65107
Rat
RGD:1310471
305880
Dog
LDL receptor related protein 10
VGNC:42772
608002
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LDL receptor related protein 10
Macaque
LDL receptor related protein 10
Mouse
Rat
Dog
LDL receptor related protein 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z4F1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Metabolism of fat-soluble vitamins
Metabolism of vitamins and cofactors
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (64)
1 – 10 of 64
GGA1
Tbio
Novelty:  0.00866392
p_int:  0.996185744
p_ni:  0.003814256
Score:  0.512
Data Source:  BioPlex,STRINGDB
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.987778069
p_ni:  0.012221931
Score:  0.241
Data Source:  BioPlex,STRINGDB
LITAF
Tbio
Family:  TF
Novelty:  0.0097203
p_int:  0.986911853
p_ni:  0.013088115
p_wrong:  3.2e-8
Data Source:  BioPlex
TNFRSF10A
Tchem
Novelty:  0.0003383
p_int:  0.974757579
p_ni:  0.025242367
p_wrong:  5.4e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
MRAP2
Tbio
Novelty:  0.0420503
p_int:  0.973527049
p_ni:  0.026472797
p_wrong:  1.53e-7
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.9703062
p_ni:  0.029693567
p_wrong:  2.33e-7
Data Source:  BioPlex
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.965919358
p_ni:  0.034080639
p_wrong:  2e-9
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.962952599
p_ni:  0.037047398
p_wrong:  3e-9
Data Source:  BioPlex
SLC20A1
Tbio
Family:  Transporter
Novelty:  0.01123373
p_int:  0.961562132
p_ni:  0.038437865
p_wrong:  3e-9
Score:  0.155
Data Source:  BioPlex,STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.95970103
p_ni:  0.040298961
p_wrong:  9e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  25.26

PubMed score by year
PubTator Score  12.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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