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Tbio
CLASP1
CLIP-associating protein 1

Protein Summary
Description
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (M ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263710
  • ENSP00000263710
  • ENSG00000074054
  • ENST00000397587
  • ENSP00000380717
  • ENST00000409078
  • ENSP00000386442
  • ENST00000541377
  • ENSP00000441625
  • ENST00000646274
  • ENSP00000496269

Symbol
  • KIAA0622
  • MAST1
  • MAST1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
transcription factor perturbation
0.94
cellular component
0.93
interacting protein
0.93
transcription factor binding site profile
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.14   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.14   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
2
3
3
74.6
glomerular filtration rate
2
3
3
74.6
potassium measurement
1
2
2
70.4
serum urea measurement
1
2
2
70.4
urate measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
74.6
glomerular filtration rate
3
74.6
potassium measurement
2
70.4
serum urea measurement
2
70.4
urate measurement
1
58.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytoplasmic linker associated protein 1
VGNC:140
459583
Macaque
cytoplasmic linker associated protein 1
696719
Mouse
MGI:1923957
76707
Rat
RGD:1310970
304740
Dog
cytoplasmic linker associated protein 1
VGNC:39294
100684635
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytoplasmic linker associated protein 1
Macaque
cytoplasmic linker associated protein 1
Mouse
Rat
Dog
cytoplasmic linker associated protein 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7Z460-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Axon guidance
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Anchoring of the basal body to the plasma membrane
Axon guidance
Gene Ontology Terms (50)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (251)
1 – 10 of 251
ARHGEF38
Tdark
Novelty:  0.4926213
p_int:  0.999999897
p_ni:  9.7e-8
p_wrong:  6e-9
Score:  0.485
Data Source:  BioPlex,STRINGDB
SYBU
Tbio
Novelty:  0.06029092
p_int:  0.999902361
p_ni:  0.000092763
p_wrong:  0.000004876
Score:  0.601
Data Source:  BioPlex,STRINGDB
BSG
Tbio
Novelty:  0.0010285
p_int:  0.973334939
p_ni:  0.000025686
p_wrong:  0.026639375
Data Source:  BioPlex
CLIP1
Tbio
Novelty:  0.00399891
Score:  0.987
Data Source:  STRINGDB
KIF2B
Tbio
Novelty:  0.09958244
Score:  0.968
Data Source:  STRINGDB
KIF2C
Tbio
Novelty:  0.00498643
Score:  0.964
Data Source:  STRINGDB
ZW10
Tbio
Novelty:  0.01680538
Score:  0.963
Data Source:  STRINGDB
MAPRE1
Tbio
Novelty:  0.01267772
Score:  0.961
Data Source:  STRINGDB
CKAP5
Tbio
Novelty:  0.00623771
Score:  0.958
Data Source:  STRINGDB
PAFAH1B1
Tbio
Family:  Enzyme
Novelty:  0.00256206
Score:  0.956
Data Source:  STRINGDB
Publication Statistics
PubMed Score  38.14

PubMed score by year
PubTator Score  15.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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