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Tbio
CYP2U1
Cytochrome P450 2U1

Protein Summary
Description
Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332884
  • ENSP00000333212
  • ENSG00000155016

Symbol
  • SPG49
  • SPG56
  • P450TEC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
kinase perturbation
0.88
cell type or tissue
0.82
virus perturbation
0.76
molecular function
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.76   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.76   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (19)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Disease
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (61)
1 – 10 of 61
CYP4F8
Tbio
Novelty: 0.06814051
Score: 0.935
Data Source: STRINGDB
CYP4F3
Tbio
Family: Enzyme
Novelty: 0.01392719
Score: 0.934
Data Source: STRINGDB
CYP4F2
Tchem
Family: Enzyme
Novelty: 0.0050361
Score: 0.931
Data Source: STRINGDB
CYP4A11
Tbio
Novelty: 0.01121493
Score: 0.931
Data Source: STRINGDB
CYP2E1
Tchem
Novelty: 0.00030504
Score: 0.913
Data Source: STRINGDB
CYP2J2
Tchem
Novelty: 0.00534181
Score: 0.913
Data Source: STRINGDB
CYP2C9
Tchem
Novelty: 0.00041914
Score: 0.91
Data Source: STRINGDB
CYP2C19
Tchem
Novelty: 0.000394
Score: 0.91
Data Source: STRINGDB
CYP2B6
Tchem
Novelty: 0.00018351
Score: 0.909
Data Source: STRINGDB
CYP2C8
Tchem
Novelty: 0.00186373
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.76

PubMed score by year
PubTator Score  22.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer