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Tbio
PKD1L2
Polycystic kidney disease protein 1-like 2

Protein Summary
Description
May function as an ion-channel regulator. May function as a G-protein-coupled receptor. This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, and the reference genome encodes a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2019]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337114
  • ENSP00000337397
  • ENSG00000166473
  • ENST00000527937
  • ENSP00000432818
  • ENST00000531391
  • ENSP00000436309

Symbol
  • KIAA1879
  • PC1L2
  • PC1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
microRNA
0.84
virus perturbation
0.68
tissue
0.63
trait
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.28   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.28   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0