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Tbio
MAVS
Mitochondrial antiviral-signaling protein

Protein Summary
Description
Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of t ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
histone modification site profile
0.81
kinase perturbation
0.76
cellular component
0.75
hub protein
0.75


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.29   (req: < 5)
Gene RIFs: 139   (req: <= 3)
Antibodies: 564   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.29   (req: >= 5)
Gene RIFs: 139   (req: > 3)
Antibodies: 564   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial antiviral signaling protein
VGNC:6186
470026
Macaque
mitochondrial antiviral signaling protein
717616
Mouse
MGI:2444773
228607
Rat
RGD:1359371
311430
Dog
mitochondrial antiviral signaling protein
VGNC:43044
485789
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial antiviral signaling protein
Macaque
mitochondrial antiviral signaling protein
Mouse
Rat
Dog
mitochondrial antiviral signaling protein
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (29)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Deubiquitination
Immune System
Innate Immune System
Metabolism of proteins
Gene Ontology Terms (37)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (221)
1 – 10 of 221
SOD1
Tbio
Family: Enzyme
Novelty: 0.00039653
p_int: 0.999991973
p_ni: 0.000008027
Score: 0.21
Data Source: BioPlex,STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
p_int: 0.986239922
p_ni: 0.013760078
Score: 0.53
Data Source: BioPlex,STRINGDB
VAC14
Tbio
Novelty: 0.02677738
p_int: 0.975444484
p_ni: 0.024555475
p_wrong: 4.1e-8
Data Source: BioPlex
SLC7A1
Tbio
Family: Transporter
Novelty: 0.00197313
p_int: 0.967988869
p_ni: 0.032011131
Data Source: BioPlex
SLC39A12
Tbio
Family: Transporter
Novelty: 0.09127395
p_int: 0.965807025
p_ni: 0.034192955
p_wrong: 1.9e-8
Data Source: BioPlex
HSPA9
Tbio
Novelty: 0.00235171
p_int: 0.965219909
p_ni: 0.034780091
Score: 0.227
Data Source: BioPlex,STRINGDB
KPTN
Tbio
Novelty: 0.06841936
p_int: 0.960746825
p_ni: 0.039253175
Data Source: BioPlex
BZW2
Tbio
Novelty: 0.17006204
p_int: 0.9408926
p_ni: 0.059107399
Data Source: BioPlex
LY86
Tbio
Novelty: 0.00314575
p_int: 0.940782329
p_ni: 0.059217671
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.925114191
p_ni: 0.074885809
Score: 0.158
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  484.29

PubMed score by year
PubTator Score  441.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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