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Tbio
RNF144B
E3 ubiquitin-protein ligase RNF144B

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259939
  • ENSP00000259939
  • ENSG00000137393

Symbol
  • IBRDC2
  • P53RFP
  • PIR2
  • IBRDC2
  • p53RFP
  • bA528A10.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
microRNA
0.74
transcription factor
0.68
transcription factor binding site profile
0.66
histone modification site profile
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.29   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 349   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.29   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
5
31.4
body height
1
1
1
9.1
body mass index
1
1
1
7.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
5
31.4
body height
1
9.1
body mass index
1
7.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 144B
VGNC:3683
462463
Mouse
MGI:2384986
218215
Rat
RGD:1308856
364681
Dog
ring finger protein 144B
VGNC:45636
488237
Horse
ring finger protein 144B
VGNC:22441
100052124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 144B
Mouse
Rat
Dog
ring finger protein 144B
Horse
ring finger protein 144B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z419-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (294)
1 – 10 of 294
UBE2L6
Tbio
Novelty:  0.03471633
Score:  0.966
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.962
Data Source:  STRINGDB
RNF130
Tdark
Family:  Enzyme
Novelty:  0.26931521
Score:  0.954
Data Source:  STRINGDB
UBOX5
Tbio
Novelty:  0.37436118
Score:  0.938
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.937
Data Source:  STRINGDB
DET1
Tbio
Novelty:  0.01138079
Score:  0.932
Data Source:  STRINGDB
UBE2E2
Tbio
Novelty:  0.02752227
Score:  0.932
Data Source:  STRINGDB
HUWE1
Tbio
Family:  Enzyme
Novelty:  0.01104129
Score:  0.931
Data Source:  STRINGDB
RNF217
Tdark
Family:  Enzyme
Novelty:  0.37676903
Score:  0.93
Data Source:  STRINGDB
UBE2K
Tbio
Novelty:  0.00214955
Score:  0.93
Data Source:  STRINGDB
Publication Statistics
PubMed Score  39.29

PubMed score by year
PubTator Score  13.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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