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Tclin
KCNK18
Potassium channel subfamily K member 18

Protein Summary
Description
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334549
  • ENSP00000334650
  • ENSG00000186795

Symbol
  • TRESK
  • TRIK
  • TRIK
  • MGR13
  • TRESK
  • TRESK2
  • K2p18.1
  • TRESK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
chemical
0.49
cell type or tissue
0.46
biological term
0.42
cell line
0.41


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.65   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.65   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Active Ligands (1)
1 – 1 of 1
CHEMBL1417584
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 18
VGNC:7846
466212
Mouse
MGI:2685627
332396
Rat
RGD:1303091
445371
Dog
potassium two pore domain channel subfamily K member 18
VGNC:42273
100855576
Horse
potassium two pore domain channel subfamily K member 18
VGNC:19296
100058839
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 18
Mouse
Rat
Dog
potassium two pore domain channel subfamily K member 18
Horse
potassium two pore domain channel subfamily K member 18
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z418-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Protein-Protein Interactions (35)
1 – 10 of 35
KCNK13
Tbio
Family: IC
Novelty: 0.05332737
Score: 0.808
Data Source: STRINGDB
KCNK17
Tbio
Family: IC
Novelty: 0.04038829
Score: 0.728
Data Source: STRINGDB
KCNK12
Tbio
Family: IC
Novelty: 0.11409413
Score: 0.676
Data Source: STRINGDB
KCNK7
Tdark
Family: IC
Novelty: 0.25673931
Score: 0.674
Data Source: STRINGDB
ATP1A2
Tclin
Family: Transporter
Novelty: 0.00606202
Score: 0.647
Data Source: STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
Score: 0.626
Data Source: STRINGDB
PIRT
Tdark
Novelty: 0.03227623
Score: 0.61
Data Source: STRINGDB
KCNC2
Tclin
Family: IC
Novelty: 0.02509313
Score: 0.594
Data Source: STRINGDB
SCN1A
Tclin
Family: IC
Novelty: 0.00109424
Score: 0.561
Data Source: STRINGDB
KCNG2
Tclin
Family: IC
Novelty: 0.31296944
Score: 0.54
Data Source: STRINGDB
Publication Statistics
PubMed Score  97.65

PubMed score by year
PubTator Score  39.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer