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Tbio
PEX26
Peroxisome assembly protein 26

Protein Summary
Description
Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence. This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329627
  • ENSP00000331106
  • ENSG00000215193
  • ENST00000399744
  • ENSP00000382648
  • ENST00000428061
  • ENSP00000412441
  • ENST00000610387
  • ENSP00000482091

Symbol
  • PBD7A
  • PBD7B
  • PEX26M1T
  • Pex26pM1T
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
transcription factor binding site profile
0.77
phenotype
0.75
tissue sample
0.75
small molecule perturbation
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.37   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.37   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
71.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
71.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921293
74043
Rat
RGD:1584998
297570
Dog
peroxisomal biogenesis factor 26
VGNC:44433
477743
Horse
peroxisomal biogenesis factor 26
VGNC:21327
100054664
Cow
peroxisomal biogenesis factor 26
VGNC:32759
537878
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
peroxisomal biogenesis factor 26
Horse
peroxisomal biogenesis factor 26
Cow
peroxisomal biogenesis factor 26
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z412-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Class I peroxisomal membrane protein import (R-HSA-9603798)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class I peroxisomal membrane protein import
Reactome
Peroxisomal protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Class I peroxisomal membrane protein import
Peroxisomal protein import
Protein localization
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (49)
1 – 10 of 49
PEX6
Tbio
Family: Enzyme
Novelty: 0.00874708
Score: 0.993
Data Source: Reactome,STRINGDB
PEX1
Tbio
Family: Enzyme
Novelty: 0.08400632
Score: 0.988
Data Source: Reactome,STRINGDB
PEX10
Tbio
Novelty: 0.0174463
Score: 0.98
Data Source: Reactome,STRINGDB
PEX12
Tbio
Novelty: 0.02252744
Score: 0.98
Data Source: Reactome,STRINGDB
PEX2
Tbio
Novelty: 0.01015599
Score: 0.975
Data Source: Reactome,STRINGDB
PEX13
Tbio
Novelty: 0.01777214
Score: 0.974
Data Source: Reactome,STRINGDB
PEX7
Tbio
Novelty: 0.01487923
Score: 0.974
Data Source: Reactome,STRINGDB
PEX14
Tbio
Novelty: 0.0210557
Score: 0.97
Data Source: Reactome,STRINGDB
USP9X
Tbio
Family: Enzyme
Novelty: 0.00820155
Score: 0.95
Data Source: STRINGDB
ZFAND6
Tbio
Novelty: 0.08904571
Score: 0.945
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  20.37

PubMed score by year
PubTator Score  10.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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