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Tchem
MYH14
Myosin-14

Protein Summary
Description
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376970
  • ENSP00000366169
  • ENSG00000105357
  • ENST00000425460
  • ENSP00000407879
  • ENST00000596571
  • ENSP00000472819
  • ENST00000598205
  • ENSP00000472543
  • ENST00000601313
  • ENSP00000470298
  • ENST00000642316
  • ENSP00000493594

Symbol
  • KIAA2034
  • DFNA4
  • MHC16
  • MYH17
  • PNMHH
  • DFNA4A
  • myosin
  • FP17425
  • NMHC II-C
  • NMHC-II-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.95
cellular component
0.79
protein domain
0.73
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.58   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.58   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1