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Tbio
DENND4A
C-myc promoter-binding protein

Protein Summary
Description
Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter. This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431932
  • ENSP00000396830
  • ENSG00000174485
  • ENST00000443035
  • ENSP00000391167

Symbol
  • IRLB
  • MYCPBP
  • IRLB
  • MYCPBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
co-expressed gene
0.76
virus perturbation
0.76
histone modification site profile
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (47)
1 – 10 of 47
PTPRA
Tchem
Family:  Enzyme
Novelty:  0.01392344
p_int:  0.999927511
p_ni:  0.000072473
p_wrong:  1.5e-8
Score:  0.209
Data Source:  BioPlex,STRINGDB
METTL6
Tdark
Family:  Enzyme
Novelty:  0.43606491
p_int:  0.999447019
p_ni:  0.00055298
p_wrong:  1e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.948067071
p_ni:  0.050775166
p_wrong:  0.001157763
Data Source:  BioPlex
SCRN1
Tbio
Family:  Enzyme
Novelty:  0.08315012
p_int:  0.947408445
p_ni:  0.003348433
p_wrong:  0.049243122
Score:  0.187
Data Source:  BioPlex,STRINGDB
ASB3
Tbio
Novelty:  0.15921018
p_int:  0.901826248
p_ni:  0.001694009
p_wrong:  0.096479743
Score:  0.179
Data Source:  BioPlex,STRINGDB
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
p_int:  0.887240836
p_ni:  0.00198182
p_wrong:  0.110777344
Score:  0.179
Data Source:  BioPlex,STRINGDB
RAB10
Tbio
Family:  Enzyme
Novelty:  0.00870713
Score:  0.947
Data Source:  Reactome,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
Score:  0.902
Data Source:  Reactome,STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
Score:  0.902
Data Source:  Reactome,STRINGDB
GDI2
Tbio
Novelty:  0.02861013
Score:  0.9
Data Source:  Reactome,STRINGDB
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
5
4
5
98.8
hemoglobin measurement
4
4
4
90.4
self reported educational attainment
5
5
4
6.4
90.3
mean corpuscular hemoglobin
2
2
2
89.5
mean corpuscular volume
3
2
3
87.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
5
98.8
hemoglobin measurement
4
90.4
self reported educational attainment
4
6.4
90.3
mean corpuscular hemoglobin
2
89.5
mean corpuscular volume
3
87.1
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DENN domain containing 4A
VGNC:6461
467708
Macaque
DENN domain containing 4A
709675
Mouse
MGI:2142979
102442
Dog
DENN domain containing 4A
VGNC:39890
487608
Horse
DENN domain containing 4A
VGNC:17124
100053090
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DENN domain containing 4A
Macaque
DENN domain containing 4A
Mouse
Dog
DENN domain containing 4A
Horse
DENN domain containing 4A
Publication Statistics
PubMed Score 4.00
PubMed score by year
PubTator Score 7.62
PubTator score by year