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Tbio
PIWIL4
Piwi-like protein 4

Protein Summary
Description
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Does not show endonuclease activity (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slice ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299001
  • ENSP00000299001
  • ENSG00000134627
  • ENST00000446230
  • ENSP00000413838
  • ENST00000543336
  • ENSP00000444575

Symbol
  • HIWI2
  • PIWI
  • HIWI2
  • MIWI2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
cell line
0.65
cellular component
0.59
biological process
0.54
tissue sample
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 978.42   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 978.42   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
30.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
piwi like RNA-mediated gene silencing 4
VGNC:10281
451490
Macaque
piwi like RNA-mediated gene silencing 4
697947
Mouse
MGI:3041167
330890
Rat
RGD:1311015
689972
Dog
piwi like RNA-mediated gene silencing 4
VGNC:44594
485123
Species
Name
OMA
EggNOG
Inparanoid
Chimp
piwi like RNA-mediated gene silencing 4
Macaque
piwi like RNA-mediated gene silencing 4
Mouse
Rat
Dog
piwi like RNA-mediated gene silencing 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z3Z4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (101)
1 – 10 of 101
TDRD9
Tbio
Family:  Epigenetic
Novelty:  0.10913126
Score:  0.991
Data Source:  Reactome,STRINGDB
TDRD1
Tbio
Family:  Epigenetic
Novelty:  0.04645566
Score:  0.988
Data Source:  STRINGDB
MOV10L1
Tbio
Family:  Enzyme
Novelty:  0.09735465
Score:  0.986
Data Source:  STRINGDB
TDRKH
Tbio
Family:  Epigenetic
Novelty:  0.0875409
Score:  0.983
Data Source:  Reactome,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.981
Data Source:  STRINGDB
MAEL
Tbio
Novelty:  0.01925239
Score:  0.979
Data Source:  Reactome,STRINGDB
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
Score:  0.976
Data Source:  Reactome,STRINGDB
DDX4
Tbio
Family:  Enzyme
Novelty:  0.00692586
Score:  0.964
Data Source:  STRINGDB
TDRD5
Tdark
Family:  Epigenetic
Novelty:  0.115495
Score:  0.962
Data Source:  STRINGDB
TDRD12
Tdark
Family:  Epigenetic
Novelty:  0.2276017
Score:  0.958
Data Source:  STRINGDB
Publication Statistics
PubMed Score  978.42

PubMed score by year
PubTator Score  19.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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