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Tbio
PIWIL3
Piwi-like protein 3

Protein Summary
Description
May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thou ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332271
  • ENSP00000330031
  • ENSG00000184571
  • ENST00000616349
  • ENSP00000479524

Symbol
  • HIWI3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.69
tissue
0.54
protein domain
0.41
microRNA
0.4
biological process
0.37


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.67   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.67   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
14
14
99.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
14
99.8
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
piwi like RNA-mediated gene silencing 3
VGNC:10110
473290
Macaque
piwi like RNA-mediated gene silencing 3
711967
Dog
piwi-like protein 1
486307
Horse
piwi like RNA-mediated gene silencing 3
VGNC:21483
100059625
Cow
piwi like RNA-mediated gene silencing 3
VGNC:32929
615479
Species
Name
OMA
EggNOG
Inparanoid
Chimp
piwi like RNA-mediated gene silencing 3
Macaque
piwi like RNA-mediated gene silencing 3
Dog
piwi-like protein 1
Horse
piwi like RNA-mediated gene silencing 3
Cow
piwi like RNA-mediated gene silencing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z3Z3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (23)
1 – 10 of 23
DICER1
Tbio
Family:  Enzyme
Novelty:  0.000306
Score:  0.821
Data Source:  STRINGDB
RNF17
Tbio
Family:  Epigenetic
Novelty:  0.09240471
Score:  0.717
Data Source:  STRINGDB
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
Score:  0.714
Data Source:  STRINGDB
TDRD7
Tbio
Family:  Epigenetic
Novelty:  0.03580848
Score:  0.655
Data Source:  STRINGDB
TDRKH
Tbio
Family:  Epigenetic
Novelty:  0.0875409
Score:  0.653
Data Source:  STRINGDB
TDRD15
Tdark
Family:  Epigenetic
Novelty:  0.68139902
Score:  0.641
Data Source:  STRINGDB
MAEL
Tbio
Novelty:  0.01925239
Score:  0.588
Data Source:  STRINGDB
TDRD9
Tbio
Family:  Epigenetic
Novelty:  0.10913126
Score:  0.564
Data Source:  STRINGDB
TDRD1
Tbio
Family:  Epigenetic
Novelty:  0.04645566
Score:  0.562
Data Source:  STRINGDB
STK31
Tchem
Family:  Kinase
Novelty:  0.12405945
Score:  0.556
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.67

PubMed score by year
PubTator Score  7.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer