Tbio RD3 Protein RD3

Protein Summary

Description

This gene encodes a retinal protein that is associated with promyelocytic leukemia-gene product (PML) bodies in the nucleus. Mutations in this gene cause Leber congenital amaurosis type 12, a disease that results in retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q7Z3Z2
• A8K595

Gene Name

• RD3

Ensembl ID

• ENST00000367002
• ENSP00000355969
• ENSG00000198570

Symbol

• C1orf36
• LCA12
• C1orf36

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.68
cell line	0.64
microRNA	0.61
chemical	0.41
disease	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.18   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 62   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.18   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0