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Tbio
KRT25
Keratin, type I cytoskeletal 25

Protein Summary
Description
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (PubMed:26902920). This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312150
  • ENSP00000310573
  • ENSG00000204897

Symbol
  • KRT25A
  • ARWH3
  • KRT25A
  • KRT24IRS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.67
cellular component
0.56
tissue
0.55
cell line
0.52
gene perturbation
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.47   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.47   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
KRT71
Tbio
Novelty:  0.06565294
Score:  0.948
Data Source:  STRINGDB
KRT74
Tbio
Novelty:  0.12747273
Score:  0.941
Data Source:  STRINGDB
KRT85
Tbio
Novelty:  0.09341199
Score:  0.938
Data Source:  STRINGDB
KRT83
Tbio
Novelty:  0.08422073
Score:  0.934
Data Source:  STRINGDB
KRT82
Tdark
Novelty:  0.5488139
Score:  0.933
Data Source:  STRINGDB
KRT86
Tbio
Novelty:  0.01021995
Score:  0.932
Data Source:  STRINGDB
KRT72
Tbio
Novelty:  0.06391566
Score:  0.931
Data Source:  STRINGDB
KRT4
Tbio
Novelty:  0.00434637
Score:  0.931
Data Source:  STRINGDB
KRT79
Tbio
Novelty:  0.07935891
Score:  0.931
Data Source:  STRINGDB
KRT76
Tdark
Novelty:  0.87892674
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1
69.6
balding measurement
1
1
1
5.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
69.6
balding measurement
1
5.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 25
VGNC:9355
468237
Macaque
keratin 25
701915
Mouse
MGI:1918060
70810
Rat
RGD:1359097
303519
Dog
keratin 25
VGNC:49880
100686957
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 25
Macaque
keratin 25
Mouse
Rat
Dog
keratin 25
Publication Statistics
PubMed Score 4.47
PubMed score by year
PubTator Score 33.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title