Tbio KRT26 Keratin, type I cytoskeletal 26

Protein Summary

Description

The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin genes on chromosome 17q21. [provided by RefSeq, Jul 2009]

Uniprot Accession IDs

• Q7Z3Y9
• A2RUL2
• B2RNH8

Gene Name

• KRT26

Ensembl ID

• ENST00000335552
• ENSP00000334798
• ENSG00000186393

Symbol

• KRT25B
• K25
• K26
• CK26
• KRT25B
• K25IRS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.61
cellular component	0.6
gene perturbation	0.49
cell line	0.46
transcription factor	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.34   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.34   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (62)

Explore Interacting Targets

1 – 10 of 62

• See Interactions on String-DB

KRT74

Tbio

Novelty:  0.12747273

Score:  0.923

Data Source:  STRINGDB

KRT71

Tbio

Novelty:  0.06565294

Score:  0.922

Data Source:  STRINGDB

KRT85

Tbio

Novelty:  0.09341199

Score:  0.921

Data Source:  STRINGDB

KRT73

Tdark

Novelty:  0.36334003

Score:  0.92

Data Source:  STRINGDB

KRT2

Tbio

Novelty:  0.01448252

Score:  0.918

Data Source:  STRINGDB

KRT6A

Tbio

Novelty:  0.00789111

Score:  0.914

Data Source:  STRINGDB

KRT6C

Tbio

Novelty:  0.11659743

Score:  0.914

Data Source:  STRINGDB

KRT39

Tdark

Novelty:  0.33252177

Score:  0.913

Data Source:  STRINGDB

KRT3

Tbio

Novelty:  0.00489796

Score:  0.913

Data Source:  STRINGDB

KRT81

Tbio

Novelty:  0.05514238

Score:  0.911

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (2)

KEGG (2)

Developmental Biology (R-HSA-1266738)

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1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Keratinization	217 targets	R-HSA-6805567

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Keratinization	217 targets	R-HSA-6805567

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (1)

Components (3)

Processes (2)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
structural molecule activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
asthma	EFO_0000270	3	2	0	1	69.6
balding measurement	EFO_0007825	1	1	1		5.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
asthma	EFO_0000270	0	1	69.6
balding measurement	EFO_0007825	1		5.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Coiled coil
Complete proteome
Intermediate filament
Keratin
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
asthma
balding measurement

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	keratin 26	VGNC:9356	468238
Macaque	keratin 26		702040
Mouse	keratin 26	MGI:2444913	320864
Rat	keratin 26	RGD:1303322	407758
Dog	keratin 26	VGNC:42524	491008

Species	Name	OMA	EggNOG	Inparanoid
Chimp	keratin 26
Macaque	keratin 26
Mouse	keratin 26
Rat	keratin 26
Dog	keratin 26

Publication Statistics

PubMed Score 30.34

PubMed score by year

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PubTator Score 13.89

PubTator score by year

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Related Publications

Text Mined References (5)

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10

0 of 0

PMID	Year	Title