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Tbio
UBE3B
Ubiquitin-protein ligase E3B

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively splice ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340074
  • ENSP00000342614
  • ENSG00000151148
  • ENST00000342494
  • ENSP00000340596
  • ENST00000434735
  • ENSP00000391529
  • ENST00000449510
  • ENSP00000395802
  • ENST00000536398
  • ENSP00000440585
  • ENST00000540230
  • ENSP00000443565

Symbol
  • KOS
  • BPIDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
kinase perturbation
0.84
transcription factor perturbation
0.84
tissue sample
0.77
transcription factor binding site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.13   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.13   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
6
3
11
93.9
monocyte count
1
1
1
70.5
insomnia measurement
1
2
0
1.1
63
cigarettes per day measurement
1
1
1
62.6
total cholesterol measurement
2
3
3
60.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
11
93.9
monocyte count
1
70.5
insomnia measurement
0
1.1
63
cigarettes per day measurement
1
62.6
total cholesterol measurement
3
60.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3B
VGNC:5642
452223
Macaque
ubiquitin protein ligase E3B
707324
Mouse
MGI:1891295
117146
Rat
RGD:1583074
687633
Dog
ubiquitin protein ligase E3B
VGNC:48069
486311
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3B
Macaque
ubiquitin protein ligase E3B
Mouse
Rat
Dog
ubiquitin protein ligase E3B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z3V4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (306)
1 – 10 of 306
MYL12B
Tbio
Novelty: 0.00999083
p_int: 0.99999834
p_ni: 0.000001658
p_wrong: 1e-9
Data Source: BioPlex
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.999996917
p_ni: 0.000003083
Data Source: BioPlex
IFI30
Tbio
Family: Enzyme
Novelty: 0.00939681
p_int: 0.999992956
p_ni: 9.49e-7
p_wrong: 0.000006095
Score: 0.226
Data Source: BioPlex,STRINGDB
DLK1
Tchem
Novelty: 0.00212394
p_int: 0.999981741
p_ni: 0.000018258
p_wrong: 1e-9
Score: 0.241
Data Source: BioPlex,STRINGDB
UBE2G1
Tbio
Novelty: 0.07307944
Score: 0.949
Data Source: STRINGDB
UBE2S
Tbio
Novelty: 0.00363304
Score: 0.949
Data Source: STRINGDB
UBE2Q2
Tbio
Novelty: 0.12491522
Score: 0.942
Data Source: STRINGDB
UBE2Q1
Tbio
Novelty: 0.06489765
Score: 0.942
Data Source: STRINGDB
UBE2A
Tbio
Novelty: 0.01670792
Score: 0.94
Data Source: STRINGDB
UBR4
Tbio
Family: Enzyme
Novelty: 0.03924839
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.13

PubMed score by year
PubTator Score  19.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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