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Tbio
ZFYVE16
Zinc finger FYVE domain-containing protein 16

Protein Summary
Description
May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338008
  • ENSP00000337159
  • ENSG00000039319
  • ENST00000505560
  • ENSP00000426848
  • ENST00000510158
  • ENSP00000423663

Symbol
  • KIAA0305
  • PPP1R69
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
microRNA
0.81
histone modification site profile
0.79
transcription factor binding site profile
0.76
transcription factor
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.08   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.08   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
32.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
32.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger FYVE-type containing 16
VGNC:14164
461775
Macaque
zinc finger FYVE-type containing 16
710872
Mouse
MGI:2145181
218441
Rat
RGD:1564784
499508
Dog
zinc finger FYVE-type containing 16
VGNC:48623
479167
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger FYVE-type containing 16
Macaque
zinc finger FYVE-type containing 16
Mouse
Rat
Dog
zinc finger FYVE-type containing 16
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by BMP
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by BMP
Signaling by TGF-beta family members
Protein-Protein Interactions (61)
1 – 10 of 61
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.999999954
p_ni: 2.7e-8
p_wrong: 2e-8
Score: 0.745
Data Source: BioPlex,STRINGDB
TOM1
Tbio
Novelty: 0.00725956
p_int: 0.999997787
p_ni: 0.000002211
p_wrong: 1e-9
Score: 0.854
Data Source: BioPlex,STRINGDB
ELP3
Tbio
Family: Epigenetic
Novelty: 0.0166061
p_int: 0.999993956
p_ni: 0.000006041
p_wrong: 3e-9
Data Source: BioPlex
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 0.999993613
p_ni: 2e-8
p_wrong: 0.000006367
Score: 0.968
Data Source: BioPlex,STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.983
Data Source: STRINGDB
SMAD1
Tbio
Family: TF
Novelty: 0.02348173
Score: 0.968
Data Source: Reactome,STRINGDB
SMAD9
Tbio
Family: TF
Novelty: 0.00285887
Score: 0.968
Data Source: Reactome,STRINGDB
SMAD5
Tbio
Family: TF
Novelty: 0.00405952
Score: 0.967
Data Source: Reactome,STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.964
Data Source: STRINGDB
SMAD7
Tbio
Family: TF
Novelty: 0.00116343
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.08

PubMed score by year
PubTator Score  2.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer