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Tbio
NOTCH2NLA
Notch homolog 2 N-terminal-like protein A

Protein Summary
Description
Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000362074
  • ENSP00000354929
  • ENSG00000264343
  • ENST00000578207
  • ENSP00000464060
  • ENST00000579793
  • ENSP00000476330

Symbol
  • N2N
  • NOTCH2NL
  • N2N
  • NOTCH2NL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.64
transcription factor binding site profile
0.64
microRNA
0.62
disease
0.56
tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.57   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.57   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (28)
1 – 10 of 28
RBPJ
Tbio
Family: TF
Novelty: 0.00168834
Score: 0.803
Data Source: STRINGDB
MPP5
Tbio
Novelty: 0.01707773
Score: 0.795
Data Source: STRINGDB
MAML1
Tbio
Novelty: 0.01302751
Score: 0.725
Data Source: STRINGDB
MPP7
Tbio
Novelty: 1.59072481
Score: 0.599
Data Source: STRINGDB
ADAM10
Tchem
Family: Enzyme
Novelty: 0.00160129
Score: 0.538
Data Source: STRINGDB
ANKRD20A4
Tdark
Novelty: 5.97231181
Score: 0.508
Data Source: STRINGDB
ANKRD20A2
Tdark
Novelty: 5.6286201
Score: 0.508
Data Source: STRINGDB
FAM72B
Tdark
Novelty: 1.82513128
Score: 0.491
Data Source: STRINGDB
NBPF9
Tdark
Novelty: 0.19849774
Score: 0.488
Data Source: STRINGDB
NBPF20
Tdark
Novelty: 0.19849774
Score: 0.488
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.57

PubMed score by year
PubTator Score  4.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer