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Tbio
CACNA2D4
Voltage-dependent calcium channel subunit alpha-2/delta-4

Protein Summary
Description
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382722
  • ENSP00000372169
  • ENSG00000151062
  • ENST00000545595
  • ENSP00000442329
  • ENST00000585708
  • ENSP00000467697
  • ENST00000586184
  • ENSP00000465060
  • ENST00000588077
  • ENSP00000468530
  • ENST00000642910
  • ENSP00000494565
  • ENSG00000284953
  • ENST00000644981
  • ENSP00000494395
  • ENST00000645018
  • ENSP00000495256
  • ENST00000645225
  • ENSP00000493490
  • ENST00000646498
  • ENSP00000494913

Symbol
  • RCD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
molecular function
0.91
cell line
0.67
disease
0.55
tissue sample
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.08   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.08   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
82.6
self reported educational attainment
1
1
1
82.6
mathematical ability
1
1
1
71.1
mathematical ability
1
1
1
71.1
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
82.6
self reported educational attainment
1
82.6
mathematical ability
1
71.1
mathematical ability
1
71.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit alpha2delta 4
VGNC:8352
466912
Macaque
calcium voltage-gated channel auxiliary subunit alpha2delta 4
721703
Mouse
MGI:2442632
319734
Rat
RGD:1562038
312668
Horse
calcium voltage-gated channel auxiliary subunit alpha2delta 4 [Source:HGNC Symbol;Acc:HGNC:20202]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit alpha2delta 4
Macaque
calcium voltage-gated channel auxiliary subunit alpha2delta 4
Mouse
Rat
Horse
calcium voltage-gated channel auxiliary subunit alpha2delta 4 [Source:HGNC Symbol;Acc:HGNC:20202]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z3S7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 0 - rapid depolarisation
Reactome
Phase 2 - plateau phase
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (109)
1 – 10 of 109
CACNG1
Tbio
Family: IC
Novelty: 0.11899252
Score: 0.988
Data Source: STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
Score: 0.983
Data Source: Reactome,STRINGDB
CACNB1
Tbio
Family: IC
Novelty: 0.06568749
Score: 0.979
Data Source: Reactome,STRINGDB
CACNA1F
Tchem
Family: IC
Novelty: 0.00431963
Score: 0.977
Data Source: Reactome,STRINGDB
CACNB4
Tbio
Family: IC
Novelty: 0.01564026
Score: 0.976
Data Source: Reactome,STRINGDB
CACNB2
Tbio
Family: IC
Novelty: 0.01745218
Score: 0.973
Data Source: Reactome,STRINGDB
CACNA1C
Tclin
Family: IC
Novelty: 0.00099998
Score: 0.968
Data Source: Reactome,STRINGDB
CACNA1S
Tclin
Family: IC
Novelty: 0.00434282
Score: 0.959
Data Source: Reactome,STRINGDB
CACNA1D
Tclin
Family: IC
Novelty: 0.00314752
Score: 0.956
Data Source: Reactome,STRINGDB
CACNG4
Tbio
Family: IC
Novelty: 0.15976593
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.08

PubMed score by year
PubTator Score  5.84

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer