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Tbio
SLC46A3
Solute carrier family 46 member 3

Protein Summary
Description
The protein encoded by this gene is a member of a transmembrane protein family that transports small molecules across membranes. The encoded protein has been found in lysosomal membranes, where it can transport catabolites from the lysosomes to the cytoplasm. This protein has been shown to be an effective transporter of the cytotoxic drug maytansine, which is used in antibody-based targeting of cancer cells. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266943
  • ENSP00000266943
  • ENSG00000139508
  • ENST00000380814
  • ENSP00000370192

Symbol
  • FKSG16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
transcription factor perturbation
0.88
virus perturbation
0.85
microRNA
0.73
transcription factor binding site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
ADGRG3
Tchem
Family:  GPCR
Novelty:  0.11719468
Score:  0.696
Data Source:  STRINGDB
SLC29A3
Tbio
Family:  Transporter
Novelty:  0.01133239
Score:  0.689
Data Source:  STRINGDB
MFSD4B
Tdark
Novelty:  0.03380333
Score:  0.686
Data Source:  STRINGDB
SLC29A4
Tchem
Family:  Transporter
Novelty:  0.00772914
Score:  0.686
Data Source:  STRINGDB
MFSD14A
Tdark
Novelty:  0.2245644
Score:  0.681
Data Source:  STRINGDB
MFSD10
Tbio
Novelty:  0.12830664
Score:  0.673
Data Source:  STRINGDB
SLC25A32
Tbio
Family:  Transporter
Novelty:  0.06270404
Score:  0.603
Data Source:  STRINGDB
HDHD3
Tdark
Family:  Enzyme
Novelty:  0.51499634
Score:  0.598
Data Source:  STRINGDB
SLC29A1
Tclin
Family:  Transporter
Novelty:  0.002085
Score:  0.576
Data Source:  STRINGDB
TMEM217
Tdark
Novelty:  1.52895857
Score:  0.565
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
2
3
84.1
hematocrit
3
1
3
40.6
red blood cell density measurement
1
1
1
38.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
84.1
hematocrit
3
40.6
red blood cell density measurement
1
38.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 46 member 3
VGNC:7835
467249
Macaque
solute carrier family 46 member 3
712056
Mouse
MGI:1918956
71706
Rat
RGD:1307594
288454
Dog
solute carrier family 46 member 3
VGNC:46428
477324
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 46 member 3
Macaque
solute carrier family 46 member 3
Mouse
Rat
Dog
solute carrier family 46 member 3
Publication Statistics
PubMed Score 6.18
PubMed score by year
PubTator Score 1.60
PubTator score by year
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Related Publications
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PMID
Year
Title