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Tdark
MIER3
Mesoderm induction early response protein 3

Protein Summary
Description
Transcriptional repressor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381199
  • ENSP00000370596
  • ENSG00000155545
  • ENST00000381213
  • ENSP00000370611
  • ENST00000381226
  • ENSP00000370624
  • ENST00000409421
  • ENSP00000386584
  • ENST00000452157
  • ENSP00000408076
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.82
transcription factor perturbation
0.68
cell type or tissue
0.64
histone modification site profile
0.64
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.97   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.97   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
9
0
1.4
83
sex hormone-binding globulin measurement
4
1
4
73.7
BMI-adjusted waist-hip ratio
1
1
1
48.5
waist-hip ratio
1
1
1
46.9
C-reactive protein measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
83
sex hormone-binding globulin measurement
4
73.7
BMI-adjusted waist-hip ratio
1
48.5
waist-hip ratio
1
46.9
C-reactive protein measurement
1
38.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MIER family member 3
VGNC:7087
471542
Macaque
MIER family member 3
711063
Mouse
MGI:2442317
218613
Rat
RGD:1311241
310086
Dog
MIER family member 3
VGNC:43231
487215
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MIER family member 3
Macaque
MIER family member 3
Mouse
Rat
Dog
MIER family member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z3K6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (41)
1 – 10 of 41
C16orf87
Tdark
Novelty:  5.71664261
p_int:  0.999999983
p_ni:  1.4e-8
p_wrong:  3e-9
Score:  0.869
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999999977
p_ni:  2.2e-8
p_wrong:  1e-9
Score:  0.689
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.999999958
p_ni:  4.2e-8
Score:  0.277
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999999787
p_ni:  2.13e-7
Score:  0.662
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999941137
p_ni:  0.00005534
p_wrong:  0.000003524
Score:  0.333
Data Source:  BioPlex,STRINGDB
RASA1
Tbio
Family:  Enzyme
Novelty:  0.00425286
Score:  0.828
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.74
Data Source:  STRINGDB
CHD1
Tbio
Family:  Epigenetic
Novelty:  0.00498132
Score:  0.714
Data Source:  STRINGDB
SETD9
Tdark
Novelty:  0.36256587
Score:  0.668
Data Source:  STRINGDB
ZSWIM6
Tbio
Novelty:  0.20377569
Score:  0.58
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.97

PubMed score by year
PubTator Score  1.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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