Tbio POGZ Pogo transposable element with ZNF domain

Protein Summary

Description

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• Q7Z3K3
• B4DTP8
• B4DYL9
• B7ZBY5
• E9PM80
• O75049
• Q3LIC4
• Q5SZS1
• Q5SZS2
• Q5SZS3
• Q5SZS4
• Q8TDZ7
• Q9Y4X7

Gene Name

• POGZ

Ensembl ID

• ENST00000271715
• ENSP00000271715
• ENSG00000143442
• ENST00000368863
• ENSP00000357856
• ENST00000392723
• ENSP00000376484
• ENST00000409503
• ENSP00000386836
• ENST00000491586
• ENSP00000418408
• ENST00000531094
• ENSP00000431259

Symbol

• KIAA0461
• SUHW5
• ZNF280E
• ZNF635
• MRD37
• WHSUS
• ZNF635
• ZNF280E
• ZNF635m

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.85
kinase perturbation	0.84
microRNA	0.84
interacting protein	0.83
co-expressed gene	0.76

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Pogo Transposable Element With Znf Domain

Protein / ... / Krab Box Transcription Factor / Pogo Transposable Element With Znf Domain

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Pogo Transposable Element With Znf Domain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.28   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.28   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0