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Tdark
C16orf62
UPF0505 protein C16orf62

Protein Summary
Description
Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947).
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.94   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.94   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
COMMD6
Tbio
Novelty:  0.11854363
p_int:  0.99999979
p_ni:  2.1e-7
Score:  0.913
Data Source:  BioPlex,STRINGDB
VPS29
Tbio
Novelty:  0.01335106
p_int:  0.999999616
p_ni:  3.84e-7
Score:  0.911
Data Source:  BioPlex,STRINGDB
COMMD1
Tbio
Novelty:  0.01349432
p_int:  0.99999949
p_ni:  5.1e-7
Score:  0.946
Data Source:  BioPlex,STRINGDB
COMMD2
Tdark
Novelty:  0.62195903
p_int:  0.999999338
p_ni:  6.62e-7
Score:  0.886
Data Source:  BioPlex,STRINGDB
COMMD3
Tbio
Novelty:  0.07399068
p_int:  0.999998673
p_ni:  0.000001327
Score:  0.882
Data Source:  BioPlex,STRINGDB
COMMD10
Tbio
Novelty:  0.29057641
p_int:  0.999998516
p_ni:  0.000001484
Score:  0.901
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  0.999997413
p_ni:  0.000002587
Score:  0.85
Data Source:  BioPlex,STRINGDB
CCDC22
Tbio
Novelty:  0.01400901
p_int:  0.999995455
p_ni:  0.000004545
Score:  0.96
Data Source:  BioPlex,STRINGDB
FAM45A
Tdark
Novelty:  0.94034891
p_int:  0.999980346
p_ni:  0.000019649
p_wrong:  5e-9
Score:  0.869
Data Source:  BioPlex,STRINGDB
COMMD4
Tbio
Novelty:  0.20453574
p_int:  0.999967062
p_ni:  0.000032938
Score:  0.899
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
21.5
late-onset Alzheimers disease
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
21.5
late-onset Alzheimers disease
0
1.1
21.5
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 2.94
PubMed score by year
PubTator Score 0.94
PubTator score by year
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Related Publications
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PMID
Year
Title