Tbio ATG9A Autophagy-related protein 9A

Protein Summary

Description

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.

Uniprot Accession IDs

• Q7Z3C6
• Q3ZAQ6
• Q6P0N7
• Q7Z317
• Q7Z320
• Q8NDK6
• Q8WU65
• Q9BVL5
• Q9H6L1
• Q9HAG7

Gene Name

• ATG9A

Ensembl ID

• ENST00000361242
• ENSP00000355173
• ENSG00000198925
• ENST00000396761
• ENSP00000379983
• ENST00000409033
• ENSP00000386482
• ENST00000409422
• ENSP00000386535
• ENST00000409618
• ENSP00000386710

Symbol

• APG9L1
• mATG9
• APG9L1
• MGD3208

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.93
cellular component	0.78
hub protein	0.75
cell type or tissue	0.73
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.4   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 377   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.4   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0