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Tbio
ATG9A
Autophagy-related protein 9A

Protein Summary
Description
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361242
  • ENSP00000355173
  • ENSG00000198925
  • ENST00000396761
  • ENSP00000379983
  • ENST00000409033
  • ENSP00000386482
  • ENST00000409422
  • ENSP00000386535
  • ENST00000409618
  • ENSP00000386710

Symbol
  • APG9L1
  • mATG9
  • APG9L1
  • MGD3208
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
cellular component
0.78
hub protein
0.75
cell type or tissue
0.73
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.36   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.36   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
RGS3
Tbio
Novelty:  0.01749541
p_int:  0.999976413
p_ni:  0.00002352
p_wrong:  6.7e-8
Data Source:  BioPlex
ZFAND2B
Tbio
Novelty:  0.28286118
p_int:  0.99995997
p_ni:  0.000015486
p_wrong:  0.000024543
Data Source:  BioPlex
CD44
Tbio
Novelty:  0.00011321
p_int:  0.999922126
p_ni:  0.000077873
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.99989543
p_ni:  0.000104569
Score:  0.322
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999893578
p_ni:  0.000106419
p_wrong:  4e-9
Score:  0.165
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.999788764
p_ni:  0.000211236
p_wrong:  1e-9
Score:  0.515
Data Source:  BioPlex,STRINGDB
HERPUD1
Tbio
Novelty:  0.00793854
p_int:  0.999520533
p_ni:  0.000008772
p_wrong:  0.000470696
Score:  0.187
Data Source:  BioPlex,STRINGDB
TM2D1
Tdark
Novelty:  0.1760181
p_int:  0.995709741
p_ni:  0.004290232
p_wrong:  2.7e-8
Data Source:  BioPlex
UBXN7
Tbio
Novelty:  0.07437638
p_int:  0.993816635
p_ni:  0.005829183
p_wrong:  0.000354182
Score:  0.201
Data Source:  BioPlex,STRINGDB
SLC17A2
Tdark
Family:  Transporter
Novelty:  0.23941275
p_int:  0.988104739
p_ni:  0.011887313
p_wrong:  0.000007948
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
3
8
95.7
reticulocyte measurement
3
2
5
92.7
vitamin C measurement
1
1
1
79.9
mean reticulocyte volume
1
2
2
77.5
red blood cell distribution width
2
1
2
75.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
8
95.7
reticulocyte measurement
5
92.7
vitamin C measurement
1
79.9
mean reticulocyte volume
2
77.5
red blood cell distribution width
2
75.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 9A
VGNC:100
742932
Macaque
autophagy related 9A
702263
Mouse
MGI:2138446
245860
Rat
RGD:1310450
363254
Dog
autophagy related 9A
VGNC:38228
102154798
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 9A
Macaque
autophagy related 9A
Mouse
Rat
Dog
autophagy related 9A
Publication Statistics
PubMed Score 57.36
PubMed score by year
PubTator Score 16.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title