Tbio ATG9A Autophagy-related protein 9A

Protein Summary

Description

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.

Uniprot Accession IDs

• Q7Z3C6
• Q3ZAQ6
• Q6P0N7
• Q7Z317
• Q7Z320
• Q8NDK6
• Q8WU65
• Q9BVL5
• Q9H6L1
• Q9HAG7

Gene Name

• ATG9A

Ensembl ID

• ENST00000361242
• ENSP00000355173
• ENSG00000198925
• ENST00000396761
• ENSP00000379983
• ENST00000409033
• ENSP00000386482
• ENST00000409422
• ENSP00000386535
• ENST00000409618
• ENSP00000386710

Symbol

• APG9L1
• mATG9
• APG9L1
• MGD3208

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.93
cellular component	0.78
hub protein	0.75
cell type or tissue	0.73
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.36   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 377   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.36   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (143)

Explore Interacting Targets

1 – 10 of 143

• See Interactions on String-DB

RGS3

Tbio

Novelty:  0.01749541

p_int:  0.999976413

p_ni:  0.00002352

p_wrong:  6.7e-8

Data Source:  BioPlex

ZFAND2B

Tbio

Novelty:  0.28286118

p_int:  0.99995997

p_ni:  0.000015486

p_wrong:  0.000024543

Data Source:  BioPlex

CD44

Tbio

Novelty:  0.00011321

p_int:  0.999922126

p_ni:  0.000077873

Data Source:  BioPlex

LGALS3

Tchem

Novelty:  0.00032754

p_int:  0.99989543

p_ni:  0.000104569

Score:  0.322

Data Source:  BioPlex,STRINGDB

LGALS8

Tchem

Novelty:  0.00623836

p_int:  0.999893578

p_ni:  0.000106419

p_wrong:  4e-9

Score:  0.165

Data Source:  BioPlex,STRINGDB

LGALS9

Tchem

Novelty:  0.00381766

p_int:  0.999788764

p_ni:  0.000211236

p_wrong:  1e-9

Score:  0.515

Data Source:  BioPlex,STRINGDB

HERPUD1

Tbio

Novelty:  0.00793854

p_int:  0.999520533

p_ni:  0.000008772

p_wrong:  0.000470696

Score:  0.187

Data Source:  BioPlex,STRINGDB

TM2D1

Tdark

Novelty:  0.1760181

p_int:  0.995709741

p_ni:  0.004290232

p_wrong:  2.7e-8

Data Source:  BioPlex

UBXN7

Tbio

Novelty:  0.07437638

p_int:  0.993816635

p_ni:  0.005829183

p_wrong:  0.000354182

Score:  0.201

Data Source:  BioPlex,STRINGDB

SLC17A2

Tdark

Family:  Transporter

Novelty:  0.23941275

p_int:  0.988104739

p_ni:  0.011887313

p_wrong:  0.000007948

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (3)

KEGG (3)

Autophagy (R-HSA-9612973)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Autophagy	109 targets	R-HSA-9612973
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Macroautophagy	90 targets	R-HSA-1632852

Name	Explore in Pharos	Explore in Source
Autophagy	109 targets	R-HSA-9612973
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Macroautophagy	90 targets	R-HSA-1632852

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Components (11)

Processes (5)

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Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
endosome	Inferred from Direct Assay (IDA)	MGI
intracellular membrane-bounded organelle	Inferred from Direct Assay (IDA)	HPA
late endosome	Inferred from Direct Assay (IDA)	MGI
phagophore assembly site	Inferred from Direct Assay (IDA)	MGI
recycling endosome	Inferred from Direct Assay (IDA)	MGI
trans-Golgi network	Inferred from Direct Assay (IDA)	MGI
membrane	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
autophagosome	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
endoplasmic reticulum membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	6	3	8		95.7
reticulocyte measurement	EFO_0010700	3	2	5		92.7
vitamin C measurement	EFO_0600003	1	1	1		79.9
mean reticulocyte volume	EFO_0010701	1	2	2		77.5
red blood cell distribution width	EFO_0005192	2	1	2		75.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	8		95.7
reticulocyte measurement	EFO_0010700	5		92.7
vitamin C measurement	EFO_0600003	1		79.9
mean reticulocyte volume	EFO_0010701	2		77.5
red blood cell distribution width	EFO_0005192	2		75.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Autophagy
Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
body height
body mass index
leukocyte count
lymphocyte percentage of leukocytes
mean corpuscular volume
mean reticulocyte volume
monocyte count
neutrophil count
platelet count

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	autophagy related 9A	VGNC:100	742932
Macaque	autophagy related 9A		702263
Mouse	autophagy related 9A	MGI:2138446	245860
Rat	autophagy related 9A	RGD:1310450	363254
Dog	autophagy related 9A	VGNC:38228	102154798

Species	Name	OMA	EggNOG	Inparanoid
Chimp	autophagy related 9A
Macaque	autophagy related 9A
Mouse	autophagy related 9A
Rat	autophagy related 9A
Dog	autophagy related 9A

Publication Statistics

PubMed Score 57.36

PubMed score by year

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PubTator Score 16.07

PubTator score by year

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Related Publications

Text Mined References (43)

GeneRif Annotations (30)

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PMID	Year	Title