Protein Classes
Protein Summary
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
- ENST00000264883
- ENSP00000264883
- ENSG00000138750
- ENST00000514987
- ENSP00000421304
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.99 | ||
kinase perturbation | 0.93 | ||
transcription factor binding site profile | 0.88 | ||
histone modification site profile | 0.82 | ||
biological process | 0.67 | ||
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IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.34 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 94 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.34 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 94 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nucleoporin 54 | VGNC:747 | 461240 | |||||
Macaque | nucleoporin 54 | 700112 | ||||||
Mouse | MGI:1920460 | 269113 | ||||||
Rat | RGD:619926 | 53372 | ||||||
Dog | nucleoporin 54 | VGNC:44057 | 487813 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nucleoporin 54 | |||||
Macaque | nucleoporin 54 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nucleoporin 54 | |||||
Protein Structure (6 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (69)
Reactome (68)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 68
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Gene Ontology Terms (14)
Functions (1)
Components (3)
Processes (10)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (223)
1 – 10 of 223
NUP58
Novelty: 0.08797454
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BFSP1
Novelty: 0.01519136
p_int: 0.999997601
p_ni: 0.000002398
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
NDEL1
Novelty: 0.01241819
p_int: 0.999991173
p_ni: 0.000008827
Data Source: BioPlex
NUP62
Novelty: 0.01432724
p_int: 0.999978191
p_ni: 0.00002181
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CEP250
Novelty: 0.08014712
p_int: 0.999955853
p_ni: 0.000044147
Score: 0.183
Data Source: BioPlex,STRINGDB
LPXN
Novelty: 0.00796678
p_int: 0.999904565
p_ni: 0.000090466
p_wrong: 0.000004969
Data Source: BioPlex
HOMER1
Novelty: 0.00264721
p_int: 0.999782179
p_ni: 0.000217821
Data Source: BioPlex
NDE1
Novelty: 0.00567438
p_int: 0.999723467
p_ni: 0.000276533
Score: 0.195
Data Source: BioPlex,STRINGDB
CDK16
Family: Kinase
Novelty: 0.02579684
p_int: 0.999634532
p_ni: 0.000365468
Score: 0.159
Data Source: BioPlex,STRINGDB
COG4
Novelty: 0.03809668
p_int: 0.998434437
p_ni: 0.001565563
Data Source: BioPlex
Publication Statistics
PubMed Score 10.34
PubMed score by year
PubTator Score 4.84
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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