NUP54
Nucleoporin p54
Protein Summary
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
- ENST00000264883
- ENSP00000264883
- ENSG00000138750
- ENST00000514987
- ENSP00000421304
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.99 | ||
kinase perturbation | 0.93 | ||
transcription factor binding site profile | 0.88 | ||
histone modification site profile | 0.82 | ||
biological process | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.64 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 94 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.64 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 94 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0