Protein Summary
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
- ENST00000264883
- ENSP00000264883
- ENSG00000138750
- ENST00000514987
- ENSP00000421304
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.99 | ||
kinase perturbation | 0.93 | ||
transcription factor binding site profile | 0.88 | ||
histone modification site profile | 0.82 | ||
biological process | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.64 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 94 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.64 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 94 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (223)
BFSP1
Novelty: 0.01519136
p_int: 0.999997601
p_ni: 0.000002398
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
NUP62
Novelty: 0.01432724
p_int: 0.999978191
p_ni: 0.00002181
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CEP250
Novelty: 0.08014712
p_int: 0.999955853
p_ni: 0.000044147
Score: 0.183
Data Source: BioPlex,STRINGDB
LPXN
Novelty: 0.00796678
p_int: 0.999904565
p_ni: 0.000090466
p_wrong: 0.000004969
Data Source: BioPlex
NDE1
Novelty: 0.00567438
p_int: 0.999723467
p_ni: 0.000276533
Score: 0.195
Data Source: BioPlex,STRINGDB
CDK16
Family: Kinase
Novelty: 0.02579684
p_int: 0.999634532
p_ni: 0.000365468
Score: 0.159
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (69)
Reactome (68)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (1)
Components (3)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-X-C motif chemokine 10 measurement | 2 | 1 | 0 | 1.8 | 92.8 | ||||
blood protein measurement | 3 | 3 | 4 | 89.2 | |||||
body mass index | 3 | 2 | 4 | 78.3 | |||||
fetal genotype effect measurement | 1 | 1 | 1 | 73.6 | |||||
protein measurement | 1 | 1 | 1 | 73.6 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-X-C motif chemokine 10 measurement | 0 | 1.8 | 92.8 | ||||
blood protein measurement | 4 | 89.2 | |||||
body mass index | 4 | 78.3 | |||||
fetal genotype effect measurement | 1 | 73.6 | |||||
protein measurement | 1 | 73.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nucleoporin 54 | VGNC:747 | 461240 | |||||
Macaque | nucleoporin 54 | 700112 | ||||||
Mouse | MGI:1920460 | 269113 | ||||||
Rat | RGD:619926 | 53372 | ||||||
Dog | nucleoporin 54 | VGNC:44057 | 487813 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nucleoporin 54 | |||||
Macaque | nucleoporin 54 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nucleoporin 54 | |||||
Publication Statistics
PubMed Score 13.64
PubMed score by year
PubTator Score 4.84
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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