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Tbio
NUP54
Nucleoporin p54

Protein Summary
Description
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264883
  • ENSP00000264883
  • ENSG00000138750
  • ENST00000514987
  • ENSP00000421304
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
kinase perturbation
0.93
transcription factor binding site profile
0.88
histone modification site profile
0.82
biological process
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.02   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.02   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (223)
NUP58
Tbio
Novelty:  0.08797454
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.999997601
p_ni:  0.000002398
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999991173
p_ni:  0.000008827
Data Source:  BioPlex
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999978191
p_ni:  0.00002181
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CEP250
Tbio
Novelty:  0.08014712
p_int:  0.999955853
p_ni:  0.000044147
Score:  0.183
Data Source:  BioPlex,STRINGDB
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.999904565
p_ni:  0.000090466
p_wrong:  0.000004969
Data Source:  BioPlex
HOMER1
Tbio
Novelty:  0.00264721
p_int:  0.999782179
p_ni:  0.000217821
Data Source:  BioPlex
NDE1
Tbio
Novelty:  0.00567438
p_int:  0.999723467
p_ni:  0.000276533
Score:  0.195
Data Source:  BioPlex,STRINGDB
CDK16
Tchem
Family:  Kinase
Novelty:  0.02579684
p_int:  0.999634532
p_ni:  0.000365468
Score:  0.159
Data Source:  BioPlex,STRINGDB
COG4
Tbio
Novelty:  0.03809668
p_int:  0.998434437
p_ni:  0.001565563
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (69)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
1
1
0
1.8
81.7
body mass index
3
2
4
64.8
fetal genotype effect measurement
1
1
1
61.4
protein measurement
1
1
1
61.4
mean corpuscular hemoglobin concentration
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
0
1.8
81.7
body mass index
4
64.8
fetal genotype effect measurement
1
61.4
protein measurement
1
61.4
mean corpuscular hemoglobin concentration
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 54
VGNC:747
461240
Macaque
nucleoporin 54
700112
Mouse
MGI:1920460
269113
Rat
RGD:619926
53372
Dog
nucleoporin 54
VGNC:44057
487813
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 54
Macaque
nucleoporin 54
Mouse
Rat
Dog
nucleoporin 54
Publication Statistics
PubMed Score 11.02
PubMed score by year
PubTator Score 4.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title