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Tbio
KANSL1
KAT8 regulatory NSL complex subunit 1

Protein Summary
Description
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262419
  • ENSP00000262419
  • ENSG00000120071
  • ENST00000432791
  • ENSP00000387393
  • ENST00000572904
  • ENSP00000461484
  • ENST00000574590
  • ENSP00000461812

Symbol
  • CENP-36
  • KIAA1267
  • MSL1V1
  • NSL1
  • KDVS
  • NSL1
  • MSL1v1
  • CENP-36
  • hMSL1v1
  • KIAA1267
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
cellular component
0.78
interacting protein
0.77
virus perturbation
0.68
microRNA
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.22   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.22   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
6
4
5.8
98.7
puberty onset measurement
3
1
3
95.2
alcohol consumption measurement
2
2
2
94.1
heel bone mineral density
1
1
1
86.3
reaction time measurement
1
2
2
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
5.8
98.7
puberty onset measurement
3
95.2
alcohol consumption measurement
2
94.1
heel bone mineral density
1
86.3
reaction time measurement
2
83.8
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (99)
1 – 10 of 99
PHF20
Tbio
Family: Epigenetic
Novelty: 0.01961423
p_int: 1
Score: 0.992
Data Source: BioPlex,STRINGDB
WDR5
Tchem
Novelty: 0.0059945
p_int: 0.999999988
p_ni: 1.2e-8
Score: 0.968
Data Source: BioPlex,STRINGDB
PHF20L1
Tbio
Family: Epigenetic
Novelty: 0.23101523
p_int: 0.999999736
p_ni: 2.64e-7
Score: 0.296
Data Source: BioPlex,STRINGDB
KANSL2
Tbio
Novelty: 0.08741608
p_int: 0.999998633
p_ni: 0.000001367
Score: 0.992
Data Source: BioPlex,STRINGDB
TRAF1
Tbio
Novelty: 0.00526776
p_int: 0.999995617
p_ni: 0.000004383
Score: 0.239
Data Source: BioPlex,STRINGDB
DUS2
Tbio
Family: Enzyme
Novelty: 0.05121878
p_int: 0.999995416
p_ni: 0.000004452
p_wrong: 1.31e-7
Score: 0.369
Data Source: BioPlex,STRINGDB
MCRS1
Tbio
Novelty: 0.03404119
p_int: 0.999943333
p_ni: 0.000056667
Score: 0.981
Data Source: BioPlex,STRINGDB
FOXK2
Tbio
Family: TF
Novelty: 0.01420141
p_int: 0.999383807
p_ni: 0.000616193
Score: 0.179
Data Source: BioPlex,STRINGDB
ECI2
Tbio
Family: Enzyme
Novelty: 0.02317646
p_int: 0.992135315
p_ni: 0.007864685
Score: 0.795
Data Source: BioPlex,STRINGDB
TPM2
Tbio
Novelty: 0.00406572
p_int: 0.906038662
p_ni: 0.093958344
p_wrong: 0.000002993
Data Source: BioPlex
Publication Statistics
PubMed Score  34.22

PubMed score by year
PubTator Score  20.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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