Tbio EFL1 Elongation factor-like GTPase 1

Protein Summary

Description

Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.

Uniprot Accession IDs

• Q7Z2Z2
• A6NKY5
• B7Z6I0
• Q9H8Z6

Gene Name

• EFL1

Ensembl ID

• ENST00000268206
• ENSP00000268206
• ENSG00000140598
• ENST00000359445
• ENSP00000352418

Symbol

• EFTUD1
• FAM42A
• RIA1
• SDS2
• EFTUD1
• FAM42A
• HsT19294

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Elongation Factor-like Gtpase 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Elongation Factor-like Gtpase 1

Protein / Hydrolase / Elongation Factor-like Gtpase 1

Protein / Enzyme Modulator / G-protein / Elongation Factor-like Gtpase 1

DTO Classes

Protein / Enzyme / Hydrolase / Elongation Factor-like Gtpase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.3   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.3   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0