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Tbio
EFL1
Elongation factor-like GTPase 1

Protein Summary
Description
Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268206
  • ENSP00000268206
  • ENSG00000140598
  • ENST00000359445
  • ENSP00000352418

Symbol
  • EFTUD1
  • FAM42A
  • RIA1
  • SDS2
  • EFTUD1
  • FAM42A
  • HsT19294
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.3   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.3   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (242)
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.999991108
p_ni:  0.000008891
p_wrong:  1e-9
Score:  0.198
Data Source:  BioPlex,STRINGDB
INSYN2
Tdark
Novelty:  2.55244594
p_int:  0.999852812
p_ni:  0.000089002
p_wrong:  0.000058186
Score:  0.189
Data Source:  BioPlex,STRINGDB
PTP4A2
Tchem
Family:  Enzyme
Novelty:  0.0083639
p_int:  0.999497363
p_ni:  0.000093726
p_wrong:  0.000408911
Score:  0.215
Data Source:  BioPlex,STRINGDB
SBDS
Tbio
Novelty:  0.00818779
Score:  0.992
Data Source:  STRINGDB
EIF6
Tbio
Novelty:  0.01271382
Score:  0.914
Data Source:  STRINGDB
RPL4
Tbio
Novelty:  0.00475169
Score:  0.886
Data Source:  STRINGDB
MRTO4
Tbio
Novelty:  0.06676322
Score:  0.874
Data Source:  STRINGDB
RPL5
Tbio
Novelty:  0.00663792
Score:  0.857
Data Source:  STRINGDB
RPL11
Tbio
Novelty:  0.00448962
Score:  0.847
Data Source:  STRINGDB
RPS3
Tbio
Novelty:  0.003106
Score:  0.846
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
11
4
5.8
83.3
self reported educational attainment
3
3
2
6.4
77.1
BMI-adjusted hip circumference
1
5
5
56.2
cognitive function measurement
2
1
2
48.7
sex hormone-binding globulin measurement
2
1
2
37
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
4
5.8
83.3
self reported educational attainment
2
6.4
77.1
BMI-adjusted hip circumference
5
56.2
cognitive function measurement
2
48.7
sex hormone-binding globulin measurement
2
37
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elongation factor like GTPase 1
VGNC:2486
453590
Macaque
elongation factor like GTPase 1
713570
Mouse
MGI:2141969
101592
Rat
RGD:1306521
308789
Dog
elongation factor like GTPase 1
VGNC:40225
479061
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elongation factor like GTPase 1
Macaque
elongation factor like GTPase 1
Mouse
Rat
Dog
elongation factor like GTPase 1
Publication Statistics
PubMed Score 11.30
PubMed score by year
PubTator Score 23.74
PubTator score by year
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Related Publications
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PMID
Year
Title