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Tclin
TRPM8
Transient receptor potential cation channel subfamily M member 8

Protein Summary
Description
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outwar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324695
  • ENSP00000323926
  • ENSG00000144481
  • ENST00000409625
  • ENSP00000386771

Symbol
  • LTRPC6
  • TRPP8
  • TRPP8
  • LTRPC6
  • trp-p8
  • LTrpC-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.89
cellular component
0.81
molecular function
0.76
biological term
0.58
cell type or tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 757.88   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 456   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 757.88   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 495
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
levomenthol
Rendered image for levomenthol
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
3
41
77
99.9
6
4
0
1.1
91
2
2
0
1.2
48.3
Headache
1
1
1
26.6
Antimigraine preparation use measurement
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
77
99.9
0
1.1
91
0
1.2
48.3
Headache
1
26.6
Antimigraine preparation use measurement
1
13.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2181435
171382
Rat
RGD:620762
171384
Dog
transient receptor potential cation channel subfamily M member 8
VGNC:47879
486170
Horse
transient receptor potential cation channel subfamily M member 8
VGNC:24561
100057419
Cow
transient receptor potential cation channel subfamily M member 8
VGNC:36394
541151
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transient receptor potential cation channel subfamily M member 8
Horse
transient receptor potential cation channel subfamily M member 8
Cow
transient receptor potential cation channel subfamily M member 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z2W7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (72)
1 – 10 of 72
TRPM4
Tchem
Family:  IC
Novelty:  0.00423106
p_int:  0.999948954
p_ni:  0.000051045
p_wrong:  1e-9
Score:  0.303
Data Source:  BioPlex,STRINGDB
KCNJ11
Tclin
Family:  IC
Novelty:  0.00068183
p_int:  0.99735439
p_ni:  0.001645834
p_wrong:  0.000999776
Score:  0.29
Data Source:  BioPlex,STRINGDB
STX5
Tbio
Novelty:  0.00964918
p_int:  0.8998423
p_ni:  0.100157613
p_wrong:  8.7e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
PCNX3
Tdark
Novelty:  0.76597717
p_int:  0.824504426
p_ni:  0.175491758
p_wrong:  0.000003815
Score:  0.196
Data Source:  BioPlex,STRINGDB
TMBIM6
Tbio
Novelty:  0.00151958
p_int:  0.786840959
p_ni:  0.21303913
p_wrong:  0.000119911
Data Source:  BioPlex
TRPV1
Tclin
Family:  IC
Novelty:  0.00039493
Score:  0.954
Data Source:  STRINGDB
TRPA1
Tclin
Family:  IC
Novelty:  0.00093648
Score:  0.944
Data Source:  STRINGDB
TRPV3
Tchem
Family:  IC
Novelty:  0.00533583
Score:  0.924
Data Source:  STRINGDB
TRPV4
Tchem
Family:  IC
Novelty:  0.00111193
Score:  0.905
Data Source:  STRINGDB
TRPV2
Tchem
Family:  IC
Novelty:  0.00472952
Score:  0.891
Data Source:  STRINGDB
Publication Statistics
PubMed Score  757.88

PubMed score by year
PubTator Score  323.71

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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