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Tbio
ZC3HAV1
Zinc finger CCCH-type antiviral protein 1

Protein Summary
Description
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242351
  • ENSP00000242351
  • ENSG00000105939
  • ENST00000471652
  • ENSP00000419855

Symbol
  • ZC3HDC2
  • ZAP
  • ZC3H2
  • ARTD13
  • PARP13
  • FLB6421
  • ZC3HDC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
interacting protein
0.96
ligand (protein) perturbation
0.96
transcription factor binding site profile
0.93
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.57   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.57   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
74
heel bone mineral density
2
2
2
73.8
lymphocyte count
2
1
2
72.9
platelet crit
1
1
1
71
eosinophil percentage of leukocytes
1
1
1
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
74
heel bone mineral density
2
73.8
lymphocyte count
2
72.9
platelet crit
1
71
eosinophil percentage of leukocytes
1
67.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCCH-type containing, antiviral 1
VGNC:8796
472529
Macaque
zinc finger CCCH-type containing, antiviral 1
106997687
Rat
RGD:628694
252832
Dog
zinc finger CCCH-type containing, antiviral 1
VGNC:48563
100856206
Horse
zinc finger CCCH-type containing, antiviral 1
VGNC:52462
100064774
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCCH-type containing, antiviral 1
Macaque
zinc finger CCCH-type containing, antiviral 1
Rat
Dog
zinc finger CCCH-type containing, antiviral 1
Horse
zinc finger CCCH-type containing, antiviral 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7Z2W4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Oncogenic MAPK signaling
Reactome
Signaling by BRAF and RAF fusions
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Oncogenic MAPK signaling
Signaling by BRAF and RAF fusions
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (199)
1 – 10 of 199
HIST1H1D
Tbio
Novelty:  0.00922175
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
HIST1H1C
Tbio
Novelty:  0.00415337
p_int:  0.999999613
p_ni:  3.87e-7
Score:  0.258
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.999998283
p_ni:  0.000001717
Score:  0.23
Data Source:  BioPlex,STRINGDB
ZNF777
Tdark
Family:  TF
Novelty:  1.20195224
p_int:  0.999833691
p_ni:  0.000166309
Score:  0.307
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.99955143
p_ni:  0.00044857
Score:  0.52
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.999423996
p_ni:  0.000576004
Score:  0.292
Data Source:  BioPlex,STRINGDB
BAZ1B
Tbio
Family:  Epigenetic
Novelty:  0.02374034
p_int:  0.999349667
p_ni:  0.000279676
p_wrong:  0.000370657
Score:  0.211
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999247268
p_ni:  0.000752732
Data Source:  BioPlex
PABPC4L
Tdark
Novelty:  0.94386609
p_int:  0.999119189
p_ni:  0.000873608
p_wrong:  0.000007203
Score:  0.516
Data Source:  BioPlex,STRINGDB
KHNYN
Tdark
Novelty:  0.34058138
p_int:  0.998663949
p_ni:  0.000029105
p_wrong:  0.001306946
Data Source:  BioPlex
Publication Statistics
PubMed Score  99.57

PubMed score by year
PubTator Score  125.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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