You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
LRRC70
Leucine-rich repeat-containing protein 70

Protein Summary
Description
Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334994
  • ENSP00000399441
  • ENSG00000186105

Symbol
  • SLRN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.68
cell line
0.6
protein domain
0.58
protein complex
0.4
cell type or tissue
0.38


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.61   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
63.6
risk-taking behaviour
2
1
2
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
63.6
risk-taking behaviour
2
44.2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7Z2Q7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (13)
1 – 10 of 13
RPL12
Tbio
Novelty:  0.01176619
Score:  0.765
Data Source:  STRINGDB
IPO11
Tbio
Novelty:  0.09553616
Score:  0.755
Data Source:  STRINGDB
RPL23A
Tbio
Novelty:  0.02951947
Score:  0.73
Data Source:  STRINGDB
IPO5
Tbio
Novelty:  0.00452607
Score:  0.728
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.685
Data Source:  STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
Score:  0.547
Data Source:  STRINGDB
EVI2B
Tbio
Novelty:  0.11190124
Score:  0.448
Data Source:  STRINGDB
CMTM6
Tbio
Novelty:  0.05496447
Score:  0.444
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.61

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer