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Tbio
APTX
Aprataxin

Protein Summary
Description
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). This gene encode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309615
  • ENSP00000311547
  • ENSG00000137074
  • ENST00000379817
  • ENSP00000369145
  • ENST00000379819
  • ENSP00000369147
  • ENST00000379825
  • ENSP00000369153
  • ENST00000397172
  • ENSP00000380357
  • ENST00000436040
  • ENSP00000400806
  • ENST00000460940
  • ENSP00000418311
  • ENST00000463596
  • ENSP00000419846
  • ENST00000467331
  • ENSP00000418733
  • ENST00000468275
  • ENSP00000420263
  • ENST00000472896
  • ENSP00000417804
  • ENST00000476858
  • ENSP00000419042
  • ENST00000479656
  • ENSP00000420071
  • ENST00000482687
  • ENSP00000419289
  • ENST00000485479
  • ENSP00000418144
  • ENST00000494649
  • ENSP00000417634
  • ENST00000495360
  • ENSP00000419623

Symbol
  • AXA1
  • AOA
  • AOA1
  • AXA1
  • EAOH
  • EOAHA
  • FHA-HIT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.96
histone modification site profile
0.91
virus perturbation
0.83
cellular component
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.36   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.36   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
1
1
22.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
22.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aprataxin
VGNC:8801
465037
Macaque
aprataxin
702671
Mouse
MGI:1913658
66408
Rat
RGD:628740
259271
Dog
aprataxin
VGNC:38015
442943
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aprataxin
Macaque
aprataxin
Mouse
Rat
Dog
aprataxin
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (25)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (120)
1 – 10 of 120
XRCC4
Tbio
Novelty: 0.00305644
p_int: 0.999999999
p_ni: 1e-9
Score: 0.987
Data Source: BioPlex,STRINGDB
BAD
Tchem
Novelty: 0.01273317
p_int: 0.999850866
p_ni: 0.00014911
p_wrong: 2.4e-8
Score: 0.54
Data Source: BioPlex,STRINGDB
POLB
Tchem
Family: Enzyme
Novelty: 0.00145102
p_int: 0.998968517
p_ni: 0.000015786
p_wrong: 0.001015697
Score: 0.593
Data Source: BioPlex,STRINGDB
KIF3A
Tbio
Novelty: 0.00555124
p_int: 0.956411486
p_ni: 0.043587937
p_wrong: 5.77e-7
Score: 0.203
Data Source: BioPlex,STRINGDB
XRCC5
Tbio
Novelty: 0.00150735
Score: 0.971
Data Source: STRINGDB
LIG4
Tbio
Family: Enzyme
Novelty: 0.00412993
Score: 0.969
Data Source: STRINGDB
XRCC6
Tbio
Novelty: 0.00127955
Score: 0.962
Data Source: STRINGDB
XRCC1
Tbio
Novelty: 0.00084203
Score: 0.959
Data Source: STRINGDB
PRKDC
Tchem
Family: Kinase
Novelty: 0.00107984
Score: 0.954
Data Source: STRINGDB
DCLRE1C
Tbio
Novelty: 0.01064408
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.36

PubMed score by year
PubTator Score  111.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer