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Tbio
APTX
Aprataxin

Protein Summary
Description
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). This gene encode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309615
  • ENSP00000311547
  • ENSG00000137074
  • ENST00000379817
  • ENSP00000369145
  • ENST00000379819
  • ENSP00000369147
  • ENST00000379825
  • ENSP00000369153
  • ENST00000397172
  • ENSP00000380357
  • ENST00000436040
  • ENSP00000400806
  • ENST00000460940
  • ENSP00000418311
  • ENST00000463596
  • ENSP00000419846
  • ENST00000467331
  • ENSP00000418733
  • ENST00000468275
  • ENSP00000420263
  • ENST00000472896
  • ENSP00000417804
  • ENST00000476858
  • ENSP00000419042
  • ENST00000479656
  • ENSP00000420071
  • ENST00000482687
  • ENSP00000419289
  • ENST00000485479
  • ENSP00000418144
  • ENST00000494649
  • ENSP00000417634
  • ENST00000495360
  • ENSP00000419623

Symbol
  • AXA1
  • AOA
  • AOA1
  • AXA1
  • EAOH
  • EOAHA
  • FHA-HIT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.96
histone modification site profile
0.91
virus perturbation
0.83
cellular component
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.83   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.83   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0