Pharos : Target Details

Tbio

Protein Classes

Protein Summary

Description

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). This gene encode ...more

Uniprot Accession IDs

Gene Name

APTX

Ensembl ID

ENST00000309615
ENSP00000311547
ENSG00000137074
ENST00000379817
ENSP00000369145
ENST00000379819
ENSP00000369147
ENST00000379825
ENSP00000369153
ENST00000397172
ENSP00000380357
ENST00000436040
ENSP00000400806
ENST00000460940
ENSP00000418311
ENST00000463596
ENSP00000419846
ENST00000467331
ENSP00000418733
ENST00000468275
ENSP00000420263
ENST00000472896
ENSP00000417804
ENST00000476858
ENSP00000419042
ENST00000479656
ENSP00000420071
ENST00000482687
ENSP00000419289
ENST00000485479
ENSP00000418144
ENST00000494649
ENSP00000417634
ENST00000495360
ENSP00000419623

Symbol

AXA1
AOA
AOA1
AXA1
EAOH
EOAHA
FHA-HIT

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97

molecular function	0.96

histone modification site profile	0.91

virus perturbation	0.83

cellular component	0.82

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.36 (req: < 5)

View Publications

Gene RIFs: 42 (req: <= 3)

View Gene RIFs

Antibodies: 223 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.36 (req: >= 5)

Gene RIFs: 42 (req: > 3)

Antibodies: 223 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at menopause	EFO_0004704	1	1	1		22.9

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at menopause	EFO_0004704	1		22.9

Beta Count

Odds Ratio

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID
Chimp	aprataxin	VGNC:8801	465037

Macaque	aprataxin		702671

Mouse	aprataxin	MGI:1913658	66408

Rat	aprataxin	RGD:628740	259271

Dog	aprataxin	VGNC:38015	442943

Species	Name	OMA	EggNOG	Inparanoid
Chimp	aprataxin

Macaque	aprataxin

Mouse	aprataxin

Rat	aprataxin

Dog	aprataxin

Protein Data Bank (11)

1 – 5 of 11

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (1)

PathwayCommons (1)

Items per page:

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: pid	DNA-PK pathway in nonhomologous end joining	13 targets	PathwayCommons: pid

Name	Explore in Pharos	Explore in Source
DNA-PK pathway in nonhomologous end joining	13 targets	PathwayCommons: pid

Gene Ontology Terms (25)

Functions (14)

Components (5)

Processes (6)

Items per page:

1 – 10 of 14

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Direct Assay (IDA)	UniProtKB

damaged DNA binding	Inferred from Direct Assay (IDA)	UniProtKB

DNA 5'-adenosine monophosphate hydrolase activity	Inferred from Direct Assay (IDA)	UniProtKB

double-stranded DNA binding	Inferred from Direct Assay (IDA)	UniProtKB

double-stranded RNA binding	Inferred from Direct Assay (IDA)	UniProtKB

phosphoglycolate phosphatase activity	Inferred from Direct Assay (IDA)	UniProtKB

polynucleotide 3'-phosphatase activity	Inferred from Direct Assay (IDA)	UniProtKB

phosphoprotein binding	Inferred from Physical Interaction (IPI)	UniProtKB

protein N-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB

mismatched DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (120)

1 – 10 of 120

See Interactions on String-DB

XRCC4

Tbio

Novelty: 0.00305644

p_int: 0.999999999

p_ni: 1e-9

Score: 0.987

Data Source: BioPlex,STRINGDB

BAD

Tchem

Novelty: 0.01273317

p_int: 0.999850866

p_ni: 0.00014911

p_wrong: 2.4e-8

Score: 0.54

Data Source: BioPlex,STRINGDB

POLB

Tchem

Family: Enzyme

Novelty: 0.00145102

p_int: 0.998968517

p_ni: 0.000015786

p_wrong: 0.001015697

Score: 0.593

Data Source: BioPlex,STRINGDB

KIF3A

Tbio

Novelty: 0.00555124

p_int: 0.956411486

p_ni: 0.043587937

p_wrong: 5.77e-7

Score: 0.203

Data Source: BioPlex,STRINGDB

XRCC5

Tbio

Novelty: 0.00150735

Score: 0.971

Data Source: STRINGDB

LIG4

Tbio

Family: Enzyme

Novelty: 0.00412993

Score: 0.969

Data Source: STRINGDB

XRCC6

Tbio

Novelty: 0.00127955

Score: 0.962

Data Source: STRINGDB

XRCC1

Tbio

Novelty: 0.00084203

Score: 0.959

Data Source: STRINGDB

PRKDC

Tchem

Family: Kinase

Novelty: 0.00107984

Score: 0.954

Data Source: STRINGDB

DCLRE1C

Tbio

Novelty: 0.01064408

Score: 0.941

Data Source: STRINGDB

Publication Statistics

PubMed Score 131.36

PubMed score by year

PubTator Score 111.9

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

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UniProt Keyword


3D-structure

Alternative splicing

Complete proteome

Cytoplasm

Disease mutation

DNA damage

DNA repair

DNA-binding

Hydrolase

Metal-binding

GWAS Trait


age at menopause

MGI Phenotype


cellular phenotype

homeostasis/metabolism phenotype

skeleton phenotype

vision/eye phenotype