Protein Summary
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15380105, PubMed:15044383, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). This gene encode ...more
- ENST00000309615
- ENSP00000311547
- ENSG00000137074
- ENST00000379817
- ENSP00000369145
- ENST00000379819
- ENSP00000369147
- ENST00000379825
- ENSP00000369153
- ENST00000397172
- ENSP00000380357
- ENST00000436040
- ENSP00000400806
- ENST00000460940
- ENSP00000418311
- ENST00000463596
- ENSP00000419846
- ENST00000467331
- ENSP00000418733
- ENST00000468275
- ENSP00000420263
- ENST00000472896
- ENSP00000417804
- ENST00000476858
- ENSP00000419042
- ENST00000479656
- ENSP00000420071
- ENST00000482687
- ENSP00000419289
- ENST00000485479
- ENSP00000418144
- ENST00000494649
- ENSP00000417634
- ENST00000495360
- ENSP00000419623
- AXA1
- AOA
- AOA1
- AXA1
- EAOH
- EOAHA
- FHA-HIT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.97 | ||
molecular function | 0.96 | ||
histone modification site profile | 0.91 | ||
virus perturbation | 0.83 | ||
cellular component | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.88 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 223 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.88 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 223 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (120)
XRCC4
Novelty: 0.00305644
p_int: 0.999999999
p_ni: 1e-9
Score: 0.987
Data Source: BioPlex,STRINGDB
BAD
Novelty: 0.01273317
p_int: 0.999850866
p_ni: 0.00014911
p_wrong: 2.4e-8
Score: 0.54
Data Source: BioPlex,STRINGDB
POLB
Family: Enzyme
Novelty: 0.00145102
p_int: 0.998968517
p_ni: 0.000015786
p_wrong: 0.001015697
Score: 0.593
Data Source: BioPlex,STRINGDB
KIF3A
Novelty: 0.00555124
p_int: 0.956411486
p_ni: 0.043587937
p_wrong: 5.77e-7
Score: 0.203
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: pid | DNA-PK pathway in nonhomologous end joining | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
DNA-PK pathway in nonhomologous end joining | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (14)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 2 | 2 | 1 | 11.9 | 90.6 | ||||
urate measurement | 2 | 2 | 2 | 62.8 | |||||
self reported educational attainment | 1 | 1 | 1 | 53.7 | |||||
ferritin measurement | 1 | 1 | 1 | 50.6 | |||||
hemoglobin measurement | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
aspartate aminotransferase measurement | 1 | 11.9 | 90.6 | ||||
urate measurement | 2 | 62.8 | |||||
self reported educational attainment | 1 | 53.7 | |||||
ferritin measurement | 1 | 50.6 | |||||
hemoglobin measurement | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | aprataxin | VGNC:8801 | 465037 | |||||
Macaque | aprataxin | 702671 | ||||||
Mouse | MGI:1913658 | 66408 | ||||||
Rat | RGD:628740 | 259271 | ||||||
Dog | aprataxin | VGNC:38015 | 442943 | |||||
Publication Statistics
PubMed Score 131.88
PubMed score by year
PubTator Score 111.90
PubTator score by year
Related Publications
Text Mined References (67)
GeneRif Annotations (42)
Items per page:
0 of 0
PMID | Year | Title |
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