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Tdark
USP17L1
Ubiquitin carboxyl-terminal hydrolase 17-like protein 1

Protein Classes
Protein Summary
Description
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000529559
  • ENSP00000485364
  • ENSG00000230549

Symbol
  • USP17L
  • USP17L1P
  • USP17L1P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.89
protein domain
0.58
cell line
0.54
interacting protein
0.31
biological process
0.28


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.2   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.2   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Protein-Protein Interactions (36)
1 – 10 of 36
RCE1
Tchem
Family: Enzyme
Novelty: 0.01209847
Score: 0.901
Data Source: STRINGDB
USP17L8
Tdark
Family: Enzyme
Novelty: 9.5249549
Score: 0.9
Data Source: STRINGDB
USP17L21
Tdark
Family: Enzyme
Score: 0.9
Data Source: STRINGDB
CDC25A
Tchem
Family: Enzyme
Novelty: 0.00250149
Score: 0.9
Data Source: STRINGDB
USP17L13
Tdark
Family: Enzyme
Novelty: 11
Score: 0.9
Data Source: STRINGDB
USP17L3
Tdark
Family: Enzyme
Novelty: 6.59346186
Score: 0.9
Data Source: STRINGDB
USP17L11
Tdark
Family: Enzyme
Novelty: 122
Score: 0.9
Data Source: STRINGDB
USP17L17
Tdark
Family: Enzyme
Novelty: 26
Score: 0.9
Data Source: STRINGDB
USP17L19
Tdark
Family: Enzyme
Score: 0.9
Data Source: STRINGDB
USP17L22
Tdark
Family: Enzyme
Novelty: 32
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.20

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer