Tbio SLC16A9 Monocarboxylate transporter 9

Protein Classes

PANTHER Classes

Protein / Transporter / Monocarboxylate Transporter 9

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc16 Family Of Monocarboxylate Transporters / Monocarboxylate Transporter 9

Protein Summary

Description

Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Uniprot Accession IDs

• Q7RTY1
• Q6ZMI2
• Q9UFH8
• MCT 9

Gene Name

• SLC16A9

Ensembl ID

• ENST00000395347
• ENSP00000378756
• ENSG00000165449
• ENST00000395348
• ENSP00000378757

Symbol

• C10orf36
• MCT9
• MCT9
• C10orf36

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.95
trait	0.86
histone modification site profile	0.74
PubMedID	0.72
gene perturbation	0.71

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.14   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.14   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	3	2	4		97.1
testosterone measurement	EFO_0004908	3	1	3		96.9
blood metabolite measurement	EFO_0005664	3	6	13		96.4
acylcarnitine measurement	EFO_0005059	1	3	4		94
uric acid measurement	EFO_0004761	2	2	2		90.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	4		97.1
testosterone measurement	EFO_0004908	3		96.9
blood metabolite measurement	EFO_0005664	13		96.4
acylcarnitine measurement	EFO_0005059	4		94
uric acid measurement	EFO_0004761	2		90.4

Reset Zoom  Beta Count   Odds Ratio

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 16 member 9	VGNC:5770	450476
Macaque	solute carrier family 16 member 9		700013
Mouse	solute carrier family 16 (monocarboxylic acid transporters), member 9	MGI:1914109	66859
Dog	solute carrier family 16 member 9	VGNC:46247	488992
Horse	solute carrier family 16 member 9	VGNC:23046	100062703

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier family 16 member 9
Macaque	solute carrier family 16 member 9
Mouse	solute carrier family 16 (monocarboxylic acid transporters), member 9
Dog	solute carrier family 16 member 9
Horse	solute carrier family 16 member 9

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q7RTY1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)

Functions (2)

Components (1)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
monocarboxylic acid transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
symporter activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

• See Interactions on String-DB

CARMIL1

Tbio

Novelty: 0.04162135

Score: 0.839

Data Source: STRINGDB

SLC2A9

Tbio

Family: Transporter

Novelty: 0.00683926

Score: 0.81

Data Source: STRINGDB

PDZK1

Tbio

Novelty: 0.01129974

Score: 0.758

Data Source: STRINGDB

SLC17A1

Tbio

Family: Transporter

Novelty: 0.0127372

Score: 0.751

Data Source: STRINGDB

SLC22A11

Tclin

Family: Transporter

Novelty: 0.01343595

Score: 0.74

Data Source: STRINGDB

SLC17A3

Tbio

Family: Transporter

Novelty: 0.04671795

Score: 0.737

Data Source: STRINGDB

SLC22A12

Tclin

Family: Transporter

Novelty: 0.00318081

Score: 0.708

Data Source: STRINGDB

RREB1

Tbio

Family: TF

Novelty: 0.01394277

Score: 0.685

Data Source: STRINGDB

SLC17A4

Tdark

Family: Transporter

Novelty: 0.22518771

Score: 0.683

Data Source: STRINGDB

SLC51B

Tbio

Family: Transporter

Novelty: 0.03325003

Score: 0.618

Data Source: STRINGDB

Publication Statistics

PubMed Score  15.14

PubMed score by year

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PubTator Score  7.08

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

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UniProt Keyword Find Similar Targets

Cell membrane
Complete proteome
Membrane
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport

GWAS Trait Find Similar Targets

acylcarnitine measurement
blood metabolite measurement
chronic kidney disease
hemoglobin measurement
metabolite measurement
serum metabolite measurement
testosterone measurement
triglyceride measurement
urate measurement
uric acid measurement