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Tbio
TAS1R1
Taste receptor type 1 member 1

Protein Classes
Protein Summary
Description
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333172
  • ENSP00000331867
  • ENSG00000173662
  • ENST00000351136
  • ENSP00000312558

Symbol
  • GPR70
  • T1R1
  • TR1
  • TR1
  • T1R1
  • GM148
  • GPR70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor binding site profile
0.73
cell type or tissue
0.68
gene perturbation
0.65
tissue sample
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.62   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.62   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
87.6
2
2
2
83.6
FEV/FEC ratio
1
1
1
75.3
mean corpuscular volume
1
1
1
69
comparative body size at age 10, self-reported
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
87.6
2
83.6
FEV/FEC ratio
1
75.3
mean corpuscular volume
1
69
comparative body size at age 10, self-reported
1
58.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taste 1 receptor member 1
VGNC:7004
469785
Macaque
taste 1 receptor member 1
720987
Mouse
MGI:1927505
110326
Rat
RGD:61891
29407
Dog
taste 1 receptor member 1
VGNC:47112
489633
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taste 1 receptor member 1
Macaque
taste 1 receptor member 1
Mouse
Rat
Dog
taste 1 receptor member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7RTX1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Protein-Protein Interactions (259)
1 – 10 of 259
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.982
Data Source:  STRINGDB
TAS2R13
Tchem
Family:  GPCR
Novelty:  0.25394315
Score:  0.967
Data Source:  STRINGDB
TAS2R5
Tchem
Family:  GPCR
Novelty:  0.08512891
Score:  0.966
Data Source:  STRINGDB
TAS2R4
Tchem
Family:  GPCR
Novelty:  0.02938385
Score:  0.965
Data Source:  STRINGDB
TAS2R38
Tchem
Family:  GPCR
Novelty:  0.004625
Score:  0.965
Data Source:  STRINGDB
TAS2R10
Tchem
Family:  GPCR
Novelty:  0.07564224
Score:  0.96
Data Source:  STRINGDB
TAS2R1
Tchem
Family:  GPCR
Novelty:  0.04676914
Score:  0.96
Data Source:  STRINGDB
TAS2R9
Tchem
Family:  GPCR
Novelty:  0.27583951
Score:  0.958
Data Source:  STRINGDB
TAS2R16
Tchem
Family:  GPCR
Novelty:  0.03181719
Score:  0.957
Data Source:  STRINGDB
TAS2R60
Tchem
Family:  GPCR
Novelty:  0.95447184
Score:  0.956
Data Source:  STRINGDB
Publication Statistics
PubMed Score  107.62

PubMed score by year
PubTator Score  188.44

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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