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Tbio
TAS1R3
Taste receptor type 1 member 3

Protein Summary
Description
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339381
  • ENSP00000344411
  • ENSG00000169962

Symbol
  • T1R3
  • TR3
  • T1R3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
chemical
0.53
gene perturbation
0.53
biological term
0.52
cell line
0.51


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.69   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.69   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (282)
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.99
Data Source:  STRINGDB
TAS2R7
Tchem
Family:  GPCR
Novelty:  0.10029148
Score:  0.973
Data Source:  STRINGDB
TAS2R9
Tchem
Family:  GPCR
Novelty:  0.27583951
Score:  0.967
Data Source:  STRINGDB
TAS2R38
Tchem
Family:  GPCR
Novelty:  0.004625
Score:  0.966
Data Source:  STRINGDB
TAS2R5
Tchem
Family:  GPCR
Novelty:  0.08512891
Score:  0.965
Data Source:  STRINGDB
TAS2R10
Tchem
Family:  GPCR
Novelty:  0.07564224
Score:  0.962
Data Source:  STRINGDB
PYY
Tbio
Novelty:  0.00060997
Score:  0.961
Data Source:  STRINGDB
TAS2R3
Tchem
Family:  GPCR
Novelty:  0.09368884
Score:  0.958
Data Source:  STRINGDB
TAS2R4
Tchem
Family:  GPCR
Novelty:  0.02938385
Score:  0.958
Data Source:  STRINGDB
TAS2R1
Tchem
Family:  GPCR
Novelty:  0.04676914
Score:  0.955
Data Source:  STRINGDB
Pathways (8)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
56.2
intraocular pressure measurement
1
2
2
52.7
1
1
0
1.1
35
heel bone mineral density
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
56.2
intraocular pressure measurement
2
52.7
0
1.1
35
heel bone mineral density
1
6.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taste 1 receptor member 3
VGNC:8118
100610821
Mouse
MGI:1933547
83771
Rat
RGD:620539
170634
Dog
taste 1 receptor member 3
VGNC:47113
489594
Horse
taste 1 receptor member 3
VGNC:50772
100065915
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taste 1 receptor member 3
Mouse
Rat
Dog
taste 1 receptor member 3
Horse
taste 1 receptor member 3
Publication Statistics
PubMed Score 305.69
PubMed score by year
PubTator Score 91.15
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title