You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GSTA5
Glutathione S-transferase A5

Protein Summary
Description
The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284562
  • ENSP00000284562
  • ENSG00000182793
  • ENST00000370989
  • ENSP00000360028
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
protein domain
0.73
chemical
0.61
pathway
0.56
virus perturbation
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.76   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.76   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
GSTA2
Tbio
Family:  Enzyme
Novelty:  0.01131783
p_int:  1
Score:  0.979
Data Source:  BioPlex,STRINGDB
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
Score:  0.902
Data Source:  STRINGDB
GSTA1
Tchem
Family:  Enzyme
Novelty:  0.00308319
Score:  0.883
Data Source:  STRINGDB
GSTO2
Tbio
Family:  Enzyme
Novelty:  0.01836256
Score:  0.792
Data Source:  STRINGDB
GSTT2B
Tbio
Family:  Enzyme
Novelty:  0.02334158
Score:  0.777
Data Source:  STRINGDB
GSTM5
Tbio
Family:  Enzyme
Novelty:  0.03763535
Score:  0.777
Data Source:  STRINGDB
GSTO1
Tchem
Family:  Enzyme
Novelty:  0.00800915
Score:  0.775
Data Source:  STRINGDB
GPX2
Tbio
Family:  Enzyme
Novelty:  0.00479104
Score:  0.773
Data Source:  STRINGDB
GPX8
Tbio
Family:  Enzyme
Novelty:  0.02304355
Score:  0.771
Data Source:  STRINGDB
GPX6
Tdark
Family:  Enzyme
Novelty:  0.02469369
Score:  0.762
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (59)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
3
3
94.2
platelet count
4
4
4
92
triglyceride measurement
4
3
4
85.3
platelet crit
2
2
2
83.7
red blood cell distribution width
2
2
2
82.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
94.2
platelet count
4
92
triglyceride measurement
4
85.3
platelet crit
2
83.7
red blood cell distribution width
2
82.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1095417
14857
Rat
RGD:2754
24422
Platypus
glutathione S-transferase A2-like
100084704
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Platypus
glutathione S-transferase A2-like
Publication Statistics
PubMed Score 12.76
PubMed score by year
PubTator Score 4.29
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Text