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Tbio
BHLHA9
Class A basic helix-loop-helix protein 9

Protein Summary
Description
Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis. This gene is a member of the basic helix-loop-helix family. The encoded protein is a transcription factor involved in limb development. Mutations in this gene have been associated with mesoaxial synostotic syndactyly Malik-Percin type (MSSD). Copy number variation of a locus containing this gene has been linked to a form of split-hand/foot malformation with long bone deficiency (SHFLD3). [provided by RefSeq, Mar 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391429
  • ENSP00000375248
  • ENSG00000205899

Symbol
  • BHLHF42
  • CCSPD
  • BHLHF42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.75
cell line
0.58
biological process
0.44
protein complex
0.4
biological term
0.35


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.81   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.81   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basic helix-loop-helix family member a9
VGNC:9148
468133
Mouse
MGI:2444198
320522
Rat
RGD:1311234
363656
Cow
basic helix-loop-helix family member a9
VGNC:26483
100301293
Pig
basic helix-loop-helix family member a9
100521580
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basic helix-loop-helix family member a9
Mouse
Rat
Cow
basic helix-loop-helix family member a9
Pig
basic helix-loop-helix family member a9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7RTU4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (17)
1 – 10 of 17
TIMM22
Tbio
Family: Enzyme
Novelty: 0.12627933
Score: 0.755
Data Source: STRINGDB
LRRC56
Tdark
Novelty: 1.32360532
Score: 0.732
Data Source: STRINGDB
PITPNA
Tbio
Novelty: 0.01901136
Score: 0.71
Data Source: STRINGDB
TRARG1
Tbio
Novelty: 0.07729433
Score: 0.71
Data Source: STRINGDB
SFMBT1
Tbio
Family: Epigenetic
Novelty: 0.00324281
Score: 0.678
Data Source: STRINGDB
SCARF1
Tbio
Novelty: 0.00938046
Score: 0.649
Data Source: STRINGDB
YWHAE
Tbio
Novelty: 0.00431876
Score: 0.627
Data Source: STRINGDB
MYO1E
Tbio
Novelty: 0.01506519
Score: 0.606
Data Source: STRINGDB
TTC9
Tdark
Novelty: 0.1679064
Score: 0.593
Data Source: STRINGDB
MYO1C
Tbio
Novelty: 0.00967011
Score: 0.577
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.81

PubMed score by year
PubTator Score  11.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer