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Tchem
SLC29A4
Equilibrative nucleoside transporter 4

Protein Summary
Description
Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to chang ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297195
  • ENSP00000297195
  • ENSG00000164638
  • ENST00000396872
  • ENSP00000380081
  • ENST00000406453
  • ENSP00000385845

Symbol
  • ENT4
  • PMAT
  • ENT4
  • PMAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
virus perturbation
0.72
tissue sample
0.58
tissue
0.52
gene perturbation
0.49


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.84   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.84   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 29 member 4
VGNC:14087
463244
Macaque
solute carrier family 29 member 4
717249
Mouse
MGI:2385330
243328
Rat
RGD:1310545
288499
Dog
solute carrier family 29 member 4
VGNC:46336
489883
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 29 member 4
Macaque
solute carrier family 29 member 4
Mouse
Rat
Dog
solute carrier family 29 member 4
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Protein-Protein Interactions (30)
1 – 10 of 30
SLC18A2
Tclin
Family: Transporter
Novelty: 0.00072341
Score: 0.805
Data Source: STRINGDB
SLC47A1
Tchem
Family: Transporter
Novelty: 0.00535064
Score: 0.715
Data Source: STRINGDB
MFSD10
Tbio
Novelty: 0.12830664
Score: 0.699
Data Source: STRINGDB
MFSD4B
Tdark
Novelty: 0.03380333
Score: 0.694
Data Source: STRINGDB
SLC46A2
Tdark
Family: Transporter
Novelty: 0.12003352
Score: 0.687
Data Source: STRINGDB
SLC46A3
Tbio
Family: Transporter
Novelty: 0.17902241
Score: 0.686
Data Source: STRINGDB
SLC47A2
Tchem
Family: Transporter
Novelty: 0.01171254
Score: 0.681
Data Source: STRINGDB
SLC22A3
Tchem
Family: Transporter
Novelty: 0.00590004
Score: 0.678
Data Source: STRINGDB
SLC22A1
Tchem
Family: Transporter
Novelty: 0.00427728
Score: 0.668
Data Source: STRINGDB
TIMM17A
Tbio
Family: Enzyme
Novelty: 0.02095904
Score: 0.624
Data Source: STRINGDB
Publication Statistics
PubMed Score  134.84

PubMed score by year
PubTator Score  52.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer