KRT74
Keratin, type II cytoskeletal 74
Protein Summary
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]
- ENST00000305620
- ENSP00000307240
- ENSG00000170484
- K6IRS4
- KB37
- KRT5C
- KRT6IRS4
- ADWH
- HTSS2
- HYPT3
- KRT5C
- K6IRS4
- KRT6IRS4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.58 | ||
cellular component | 0.55 | ||
cell line | 0.51 | ||
phenotype | 0.44 | ||
chemical | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.52 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 46 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.52 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 46 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
keratinocyte carcinoma | 1 | 2 | 0 | 1.1 | 90.6 | ||||
4 | 1 | 1 | 1.2 | 81.2 | |||||
balding measurement | 1 | 2 | 2 | 72.5 | |||||
non-melanoma skin carcinoma | 1 | 1 | 0 | 1.3 | 54.4 | ||||
plasminogen activator inhibitor 1 measurement | 1 | 1 | 0 | 590.4 | 34.6 | ||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
keratinocyte carcinoma | 0 | 1.1 | 90.6 | ||||
1 | 1.2 | 81.2 | |||||
balding measurement | 2 | 72.5 | |||||
non-melanoma skin carcinoma | 0 | 1.3 | 54.4 | ||||
plasminogen activator inhibitor 1 measurement | 0 | 590.4 | 34.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | keratin 74 | VGNC:14414 | 466992 | |||||
Macaque | keratin 74 | 699069 | ||||||
Dog | keratin 74 | VGNC:42531 | 486521 | |||||
Cow | keratin 74 | VGNC:30738 | 525034 | |||||
Pig | keratin 74 | 100511256 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | keratin 74 | |||||
Macaque | keratin 74 | |||||
Dog | keratin 74 | |||||
Cow | keratin 74 | |||||
Pig | keratin 74 | |||||
Publication Statistics
PubMed Score 7.52
PubMed score by year
PubTator Score 11.76
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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