Tbio KRT74 Keratin, type II cytoskeletal 74

Protein Summary

Description

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]

Uniprot Accession IDs

• Q7RTS7
• B5MD61
• Q86Y45

Gene Name

• KRT74

Ensembl ID

• ENST00000305620
• ENSP00000307240
• ENSG00000170484

Symbol

• K6IRS4
• KB37
• KRT5C
• KRT6IRS4
• ADWH
• HTSS2
• HYPT3
• KRT5C
• K6IRS4
• KRT6IRS4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.58
cellular component	0.55
cell line	0.51
phenotype	0.44
chemical	0.41

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.52   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.52   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	keratin 74	VGNC:14414	466992
Macaque	keratin 74		699069
Dog	keratin 74	VGNC:42531	486521
Cow	keratin 74	VGNC:30738	525034
Pig	keratin 74		100511256

Species	Name	OMA	EggNOG	Inparanoid
Chimp	keratin 74
Macaque	keratin 74
Dog	keratin 74
Cow	keratin 74
Pig	keratin 74

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q7RTS7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)

Reactome (2)

Developmental Biology (R-HSA-1266738)

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Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Keratinization	217 targets	R-HSA-6805567

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Keratinization	217 targets	R-HSA-6805567

Gene Ontology Terms (9)

Functions (2)

Components (4)

Processes (3)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
keratin filament binding	Inferred from Physical Interaction (IPI)	UniProtKB
structural molecule activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (102)

Explore Interacting Targets

1 – 10 of 102

• See Interactions on String-DB

KRT25

Tbio

Novelty: 0.21822685

Score: 0.941

Data Source: STRINGDB

KRT27

Tdark

Novelty: 0.34729004

Score: 0.938

Data Source: STRINGDB

KRT28

Tdark

Novelty: 0.48119283

Score: 0.935

Data Source: STRINGDB

KRT35

Tbio

Novelty: 0.01111091

Score: 0.934

Data Source: STRINGDB

KRT38

Tdark

Novelty: 0.25061021

Score: 0.931

Data Source: STRINGDB

KRT24

Tbio

Novelty: 0.06581895

Score: 0.93

Data Source: STRINGDB

KRT32

Tdark

Novelty: 1.12077627

Score: 0.929

Data Source: STRINGDB

KRT14

Tbio

Novelty: 0.00088743

Score: 0.926

Data Source: STRINGDB

KRT34

Tbio

Novelty: 0.07747997

Score: 0.926

Data Source: STRINGDB

KRT37

Tdark

Novelty: 0.01643723

Score: 0.926

Data Source: STRINGDB

Publication Statistics

PubMed Score  7.52

PubMed score by year

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PubTator Score  11.76

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Coiled coil
Complete proteome
Disease mutation
Ectodermal dysplasia
Hypotrichosis
Intermediate filament
Keratin
Phosphoprotein
Polymorphism
Reference proteome