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Tbio
KRT74
Keratin, type II cytoskeletal 74

Protein Summary
Description
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305620
  • ENSP00000307240
  • ENSG00000170484

Symbol
  • K6IRS4
  • KB37
  • KRT5C
  • KRT6IRS4
  • ADWH
  • HTSS2
  • HYPT3
  • KRT5C
  • K6IRS4
  • KRT6IRS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.58
cellular component
0.55
cell line
0.51
phenotype
0.44
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.52   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.52   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
KRT25
Tbio
Novelty:  0.21822685
Score:  0.941
Data Source:  STRINGDB
KRT27
Tdark
Novelty:  0.34729004
Score:  0.938
Data Source:  STRINGDB
KRT28
Tdark
Novelty:  0.48119283
Score:  0.935
Data Source:  STRINGDB
KRT35
Tbio
Novelty:  0.01111091
Score:  0.934
Data Source:  STRINGDB
KRT38
Tdark
Novelty:  0.25061021
Score:  0.931
Data Source:  STRINGDB
KRT24
Tbio
Novelty:  0.06581895
Score:  0.93
Data Source:  STRINGDB
KRT32
Tdark
Novelty:  1.12077627
Score:  0.929
Data Source:  STRINGDB
KRT14
Tbio
Novelty:  0.00088743
Score:  0.926
Data Source:  STRINGDB
KRT34
Tbio
Novelty:  0.07747997
Score:  0.926
Data Source:  STRINGDB
KRT37
Tdark
Novelty:  0.01643723
Score:  0.926
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
keratinocyte carcinoma
1
2
0
1.1
90.6
4
1
1
1.2
81.2
balding measurement
1
2
2
72.5
non-melanoma skin carcinoma
1
1
0
1.3
54.4
plasminogen activator inhibitor 1 measurement
1
1
0
590.4
34.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
keratinocyte carcinoma
0
1.1
90.6
1
1.2
81.2
balding measurement
2
72.5
non-melanoma skin carcinoma
0
1.3
54.4
plasminogen activator inhibitor 1 measurement
0
590.4
34.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 74
VGNC:14414
466992
Macaque
keratin 74
699069
Dog
keratin 74
VGNC:42531
486521
Cow
keratin 74
VGNC:30738
525034
Pig
keratin 74
100511256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 74
Macaque
keratin 74
Dog
keratin 74
Cow
keratin 74
Pig
keratin 74
Publication Statistics
PubMed Score 7.52
PubMed score by year
PubTator Score 11.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title