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Tdark
OTOP3
Proton channel OTOP3

Protein Summary
Description
Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000580749
  • ENSP00000464577
  • ENSG00000182938
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
cell line
0.61
chemical
0.41
protein complex
0.41
tissue
0.38


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.05   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.05   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (19)
PDE8A
Tclin
Family:  Enzyme
Novelty:  0.04254335
Score:  0.655
Data Source:  STRINGDB
RGR
Tbio
Family:  GPCR
Novelty:  0.03133861
Score:  0.601
Data Source:  STRINGDB
NR2C1
Tbio
Family:  NR
Novelty:  0.03923956
Score:  0.592
Data Source:  STRINGDB
OR51G2
Tdark
Family:  oGPCR
Novelty:  7.92746114
Score:  0.59
Data Source:  STRINGDB
RNF157
Tbio
Novelty:  0.78586559
Score:  0.589
Data Source:  STRINGDB
RARRES2
Tbio
Novelty:  0.0029178
Score:  0.562
Data Source:  STRINGDB
OC90
Tbio
Novelty:  0.06959011
Score:  0.542
Data Source:  STRINGDB
RBP3
Tbio
Family:  Enzyme
Novelty:  0.00204835
Score:  0.531
Data Source:  STRINGDB
SRP68
Tbio
Novelty:  0.04666697
Score:  0.517
Data Source:  STRINGDB
GPRC5C
Tbio
Family:  GPCR
Novelty:  0.16942353
Score:  0.504
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
66.3
ferritin measurement
1
1
1
55.2
intraocular pressure measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
66.3
ferritin measurement
1
55.2
intraocular pressure measurement
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
otopetrin 3
VGNC:9498
468327
Macaque
otopetrin 3
100429258
Mouse
MGI:1916852
69602
Rat
RGD:1306663
287821
Dog
otopetrin 3
VGNC:44180
483304
Species
Name
OMA
EggNOG
Inparanoid
Chimp
otopetrin 3
Macaque
otopetrin 3
Mouse
Rat
Dog
otopetrin 3
Publication Statistics
PubMed Score 3.05
PubMed score by year
PubTator Score 0.14
PubTator score by year
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Related Publications
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PMID
Year
Title