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Tbio
NLRC3
NLR family CARD domain-containing protein 3

Protein Summary
Description
Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, contr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359128
  • ENSP00000352039
  • ENSG00000167984
  • ENST00000615877
  • ENSP00000482989

Symbol
  • NOD3
  • NOD3
  • CLR16.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
molecular function
0.73
cell line
0.68
biological process
0.63
tissue sample
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.3   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.3   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
2
5
95.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
95.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2444070
268857
Rat
RGD:1304902
287070
Dog
NLR family CARD domain containing 3
VGNC:43843
490033
Horse
NLR family CARD domain containing 3
VGNC:20764
100069521
Cow
NLR family CARD domain containing 3
VGNC:32112
507786
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
NLR family CARD domain containing 3
Horse
NLR family CARD domain containing 3
Cow
NLR family CARD domain containing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q7RTR2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
IRF3-mediated induction of type I IFN
Reactome
Immune System
Reactome
Innate Immune System
Reactome
STING mediated induction of host immune responses
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Immune System
Innate Immune System
STING mediated induction of host immune responses
Gene Ontology Terms (23)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (32)
1 – 10 of 32
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
Score: 0.941
Data Source: STRINGDB
TMEM173
Tchem
Novelty: 0.0070581
Score: 0.937
Data Source: STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.928
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.654
Data Source: STRINGDB
NAIP
Tbio
Novelty: 0.00400896
Score: 0.647
Data Source: STRINGDB
PYCARD
Tbio
Novelty: 0.00719985
Score: 0.628
Data Source: STRINGDB
NLRC4
Tbio
Novelty: 0.0032237
Score: 0.618
Data Source: STRINGDB
MEFV
Tbio
Novelty: 0.00074419
Score: 0.583
Data Source: STRINGDB
SBK1
Tchem
Family: Kinase
Novelty: 0.05227715
Score: 0.527
Data Source: STRINGDB
GNPTG
Tbio
Family: Enzyme
Novelty: 0.03345886
Score: 0.508
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.30

PubMed score by year
PubTator Score  8.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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