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Tbio
MICAL3
[F-actin]-monooxygenase MICAL3

Protein Summary
Description
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383094
  • ENSP00000372574
  • ENSG00000243156
  • ENST00000400561
  • ENSP00000383406
  • ENST00000414725
  • ENSP00000391827
  • ENST00000441493
  • ENSP00000416015
  • ENST00000585038
  • ENSP00000462033

Symbol
  • KIAA0819
  • KIAA1364
  • MICAL-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
microRNA
0.98
molecular function
0.93
protein domain
0.85
histone modification site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.69   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.69   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
3
2
3
88.4
sex hormone-binding globulin measurement
2
1
2
84.8
C-reactive protein measurement
1
1
1
75
serum gamma-glutamyl transferase measurement
1
1
0
4.8
70.8
lymphocyte count
2
2
2
62
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
3
88.4
sex hormone-binding globulin measurement
2
84.8
C-reactive protein measurement
1
75
serum gamma-glutamyl transferase measurement
0
4.8
70.8
lymphocyte count
2
62
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (59)
1 – 10 of 59
CHCHD4
Tbio
Novelty: 0.01204944
p_int: 0.999999993
p_ni: 2e-9
p_wrong: 4e-9
Data Source: BioPlex
CERKL
Tbio
Family: Enzyme
Novelty: 0.04190552
p_int: 0.999999936
p_ni: 1.1e-8
p_wrong: 5.3e-8
Score: 0.206
Data Source: BioPlex,STRINGDB
RAB8B
Tbio
Family: Enzyme
Novelty: 0.06230082
p_int: 0.999999628
p_ni: 3.15e-7
p_wrong: 5.7e-8
Score: 0.275
Data Source: BioPlex,STRINGDB
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.999996111
p_ni: 0.000003887
p_wrong: 2e-9
Score: 0.268
Data Source: BioPlex,STRINGDB
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.999743412
p_ni: 0.000256588
Score: 0.199
Data Source: BioPlex,STRINGDB
RAB8A
Tbio
Family: Enzyme
Novelty: 0.00486694
Score: 0.818
Data Source: STRINGDB
ERC1
Tbio
Novelty: 0.01251
Score: 0.672
Data Source: STRINGDB
KIF23
Tbio
Novelty: 0.00719651
Score: 0.601
Data Source: STRINGDB
PLXNA4
Tbio
Novelty: 0.01807048
Score: 0.584
Data Source: STRINGDB
NINL
Tbio
Novelty: 0.00726815
Score: 0.577
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.69

PubMed score by year
PubTator Score  3.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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