Tbio STRADA STE20-related kinase adapter protein alpha

Protein Summary

Description

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q7RTN6
• B4DDE3
• B4DW17
• J3KTC9
• Q5JPI2
• Q7Z4K9
• Q8NC31
• Q8NCF1
• Q9H272
• STRAD alpha

Gene Name

• STRADA

Ensembl ID

• ENST00000336174
• ENSP00000336655
• ENSG00000266173
• ENST00000375840
• ENSP00000365000
• ENST00000392950
• ENSP00000376677
• ENST00000447001
• ENSP00000398841
• ENST00000582137
• ENSP00000462922
• ENST00000638702
• ENSP00000491017
• ENST00000639835
• ENSP00000492578
• ENST00000640999
• ENSP00000491643

Symbol

• LYK5
• STRAD
• LYK5
• PMSE
• Stlk
• STRAD
• NY-BR-96
• STRAD alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
histone modification site profile	0.91
kinase perturbation	0.84
virus perturbation	0.72
biological process	0.67

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste20 Family / Ste20-related Kinase Adapter Protein Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.75   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 301   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.75   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0