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Tbio
CHST3
Carbohydrate sulfotransferase 3

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373115
  • ENSP00000362207
  • ENSG00000122863

Symbol
  • HSD
  • C6ST
  • C6ST1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
gene perturbation
0.7
tissue sample
0.66
transcription factor perturbation
0.61
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.67   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.67   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (16)
Chondroitin sulfate biosynthesis (R-HSA-2022870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective CHST3 causes SEDCJD
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective CHST3 causes SEDCJD
Disease
Diseases associated with glycosaminoglycan metabolism
Protein-Protein Interactions (62)
1 – 10 of 62
CRP
Tbio
Novelty: 0.0000246
p_int: 0.99999996
p_ni: 3.8e-8
p_wrong: 1e-9
Score: 0.196
Data Source: BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty: 0.01762536
p_int: 0.999994169
p_ni: 0.000005825
p_wrong: 6e-9
Data Source: BioPlex
MSMB
Tbio
Novelty: 0.00164465
p_int: 0.999612077
p_ni: 0.00018922
p_wrong: 0.000198703
Data Source: BioPlex
PTCH1
Tbio
Novelty: 0.00096312
p_int: 0.899501365
p_ni: 0.000016797
p_wrong: 0.100481838
Data Source: BioPlex
AVP
Tbio
Novelty: 0.0001163
p_int: 0.875411125
p_ni: 0.000216309
p_wrong: 0.124372566
Score: 0.195
Data Source: BioPlex,STRINGDB
CHST12
Tbio
Family: Enzyme
Novelty: 0.07210463
Score: 0.978
Data Source: STRINGDB
UST
Tbio
Family: Enzyme
Novelty: 0.00328192
Score: 0.973
Data Source: STRINGDB
CHST13
Tbio
Family: Enzyme
Novelty: 0.2520252
Score: 0.971
Data Source: STRINGDB
CHST11
Tbio
Family: Enzyme
Novelty: 0.03190916
Score: 0.971
Data Source: STRINGDB
VCAN
Tbio
Novelty: 0.00132314
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  189.67

PubMed score by year
PubTator Score  108.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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