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Tbio
RRM2B
Ribonucleoside-diphosphate reductase subunit M2 B

Protein Summary
Description
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251810
  • ENSP00000251810
  • ENSG00000048392
  • ENST00000395912
  • ENSP00000379248
  • ENST00000519317
  • ENSP00000430641
  • ENST00000519962
  • ENSP00000429140
  • ENST00000522394
  • ENSP00000429578

Symbol
  • P53R2
  • P53R2
  • MTDPS8A
  • MTDPS8B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.72
tissue sample
0.72
transcription factor binding site profile
0.72
tissue
0.69
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.58   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.58   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (169)
RRM2
Tclin
Family:  Enzyme
Novelty:  0.00112948
p_int:  1
Score:  0.972
Data Source:  BioPlex,STRINGDB
RRM1
Tclin
Family:  Enzyme
Novelty:  0.00083196
p_int:  0.999999871
p_ni:  1.28e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.99814664
p_ni:  0.00185336
p_wrong:  1e-9
Score:  0.853
Data Source:  BioPlex,STRINGDB
FZR1
Tbio
Novelty:  0.01599606
p_int:  0.986556609
p_ni:  0.013442718
p_wrong:  6.73e-7
Score:  0.515
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.948214158
p_ni:  0.051717812
p_wrong:  0.00006803
Data Source:  BioPlex
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.947956851
p_ni:  0.046814983
p_wrong:  0.005228165
Score:  0.153
Data Source:  BioPlex,STRINGDB
TMOD2
Tbio
Novelty:  0.10324176
p_int:  0.944005862
p_ni:  0.055994138
Score:  0.252
Data Source:  BioPlex,STRINGDB
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
p_int:  0.840615318
p_ni:  0.159384682
Score:  0.305
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.986
Data Source:  STRINGDB
DTYMK
Tbio
Family:  Kinase
Novelty:  0.00746576
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets (41)
Explore Nearest Tclin Targets
1 – 5 of 30
RRM2
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  6
more:  2 more common pathways
TYMS
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PDE6B
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PDE4D
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (26)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
54.4
mean corpuscular hemoglobin concentration
1
1
1
49.5
mean corpuscular volume
1
1
1
26.6
mean corpuscular hemoglobin
1
1
1
10.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
54.4
mean corpuscular hemoglobin concentration
1
49.5
mean corpuscular volume
1
26.6
mean corpuscular hemoglobin
1
10.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonucleotide reductase regulatory TP53 inducible subunit M2B
VGNC:6572
472832
Macaque
ribonucleotide reductase regulatory TP53 inducible subunit M2B
707062
Mouse
MGI:2155865
382985
Rat
RGD:1306045
299976
Dog
ribonucleotide reductase regulatory TP53 inducible subunit M2B
VGNC:51781
481988
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonucleotide reductase regulatory TP53 inducible subunit M2B
Macaque
ribonucleotide reductase regulatory TP53 inducible subunit M2B
Mouse
Rat
Dog
ribonucleotide reductase regulatory TP53 inducible subunit M2B
Publication Statistics
PubMed Score 140.58
PubMed score by year
PubTator Score 101.66
PubTator score by year
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Related Publications
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PMID
Year
Title