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Tbio
CHST15
Carbohydrate sulfotransferase 15

Protein Summary
Description
Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo. Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346248
  • ENSP00000333947
  • ENSG00000182022
  • ENST00000435907
  • ENSP00000402394
  • ENST00000628426
  • ENSP00000485905

Symbol
  • BRAG
  • GALNAC4S6ST
  • KIAA0598
  • BRAG
  • GALNAC4S-6ST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.87
molecular function
0.86
gene perturbation
0.84
transcription factor binding site profile
0.72
kinase perturbation
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.59   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.59   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 15
VGNC:10363
466249
Macaque
carbohydrate sulfotransferase 15
693845
Mouse
MGI:5011648
100502937
Rat
RGD:628881
286974
Dog
carbohydrate sulfotransferase 15
VGNC:39253
486928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 15
Macaque
carbohydrate sulfotransferase 15
Mouse
Rat
Dog
carbohydrate sulfotransferase 15
Pathways (8)
Chondroitin sulfate biosynthesis (R-HSA-2022870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (67)
1 – 10 of 67
PIN4
Tbio
Family: Enzyme
Novelty: 0.01193983
p_int: 0.992080053
p_ni: 0.005759296
p_wrong: 0.002160651
Score: 0.68
Data Source: BioPlex,STRINGDB
MORN5
Tdark
Novelty: 1.51123721
p_int: 0.992080053
p_ni: 0.005759296
p_wrong: 0.002160651
Score: 0.641
Data Source: BioPlex,STRINGDB
CANX
Tbio
Novelty: 0.00087002
p_int: 0.97975032
p_ni: 0.02024968
Score: 0.181
Data Source: BioPlex,STRINGDB
CHST14
Tbio
Family: Enzyme
Novelty: 0.026494
Score: 0.978
Data Source: STRINGDB
DSE
Tbio
Family: Enzyme
Novelty: 0.02945465
Score: 0.974
Data Source: STRINGDB
CHST12
Tbio
Family: Enzyme
Novelty: 0.04560641
Score: 0.971
Data Source: STRINGDB
CHST11
Tbio
Family: Enzyme
Novelty: 0.02528458
Score: 0.97
Data Source: STRINGDB
CHST13
Tbio
Family: Enzyme
Novelty: 0.15000853
Score: 0.97
Data Source: STRINGDB
VCAN
Tbio
Novelty: 0.00110986
Score: 0.935
Data Source: STRINGDB
DCN
Tbio
Novelty: 0.00073027
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.59

PubMed score by year
PubTator Score  27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer