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Tbio
CXXC5
CXXC-type zinc finger protein 5

Protein Summary
Description
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302517
  • ENSP00000302543
  • ENSG00000171604
  • ENST00000511048
  • ENSP00000427379

Symbol
  • CF5
  • WID
  • RINF
  • HSPC195
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
small molecule perturbation
0.93
transcription factor binding site profile
0.88
transcription factor
0.83
PubMedID
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.17   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.17   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
KANK1
Tbio
Novelty:  0.02077359
Score:  0.908
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.906
Data Source:  STRINGDB
WNT3A
Tchem
Novelty:  0.00119275
Score:  0.701
Data Source:  STRINGDB
ATP6AP1
Tchem
Family:  Enzyme
Novelty:  0.00583201
Score:  0.669
Data Source:  STRINGDB
ATP5PF
Tbio
Family:  Enzyme
Novelty:  0.00585408
Score:  0.668
Data Source:  STRINGDB
RAB20
Tbio
Family:  Enzyme
Novelty:  0.06768944
Score:  0.648
Data Source:  STRINGDB
LETMD1
Tbio
Novelty:  0.02790517
Score:  0.604
Data Source:  STRINGDB
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
Score:  0.588
Data Source:  STRINGDB
TET2
Tbio
Family:  Enzyme
Novelty:  0.00141899
Score:  0.586
Data Source:  STRINGDB
TTYH2
Tbio
Family:  IC
Novelty:  0.19796461
Score:  0.582
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
56
BMI-adjusted hip circumference
2
2
2
38.2
body mass index
2
1
2
17.3
platelet crit
1
1
1
11.1
platelet count
1
1
1
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
56
BMI-adjusted hip circumference
2
38.2
body mass index
2
17.3
platelet crit
1
11.1
platelet count
1
11.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CXXC finger protein 5
VGNC:3961
462109
Macaque
CXXC finger protein 5
694746
Mouse
MGI:1914643
67393
Rat
RGD:1359466
291670
Dog
CXXC finger protein 5
VGNC:39754
487156
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CXXC finger protein 5
Macaque
CXXC finger protein 5
Mouse
Rat
Dog
CXXC finger protein 5
Publication Statistics
PubMed Score 156.17
PubMed score by year
PubTator Score 41.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title